CC BY-NC-ND 4.0 · Journal of Gastrointestinal and Abdominal Radiology 2021; 04(01): 003-007
DOI: 10.1055/s-0040-1716605
Original Article

Yield and Safety of Transjugular Versus Percutaneous Liver Biopsies in Suspected Cases of Diffuse Liver Disease and Correlation of Yield of Transjugular Liver Biopsy with Hepatic Venous Pressure Gradient

Mousam Dey
1   Division of Radiodiagnosis, Department of Intervention Radiology, Indian Institute of Liver and Digestive Sciences, Kolkata, West Bengal, India
Simi Das
2   Department of Radiodiagnosis, Ruby General Hospital, Kolkata, West Bengal, India
Argha Chatterjee
3   Department of Radiology and Imaging, Tata Medical Center, Kolkata, West Bengal, India
Agnibha Dutta
4   Division of General Medicine, Department of Gastroenterology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India
Ranajoy Ghosh
5   Department of Pathology, GI Pathology, School of Digestive and Liver Diseases, IPGMER, Kolkata, West Bengal, India
Jayanta Dasgupta
6   Department of Gastroenterology, Indian Institute of Liver and Digestive Sciences, Kolkata, West Bengal, India
› Author Affiliations


Background Liver biopsy is indicated in both diagnosis and prognosis of diffuse liver diseases. Conventionally, percutaneous liver biopsy (PLB) is used, as it is easily available, affordable and has a shorter procedure time, whereas transjugular liver biopsy (TJLB) is used in the setting of ascites and coagulopathy. Our aim is to evaluate the diagnostic yield of TJLB in comparison to PLB with tract embolization. Our secondary aims were to evaluate whether there is any difference in rate of major and minor complications between the two procedures and evaluate whether there is any correlation between diagnostic yield of TJLB and hepatic venous pressure gradient (HVPG).

Methods In this retrospective study, we included a total of consecutive 123 patients who underwent liver biopsy through percutaneous (n = 97) and transjugular route (n = 26). We compared the yield of the specimen based on the number of complete portal tracts (CPT).

Results There was no significant difference between mean CPT in TJLB and PLB specimens (mean CPT of TJLB and PLB were 10.9 ± 2.7 and 11.6 ±2.5, respectively [p = 0.566]). There was a moderate but significant negative correlation between the total number of CPT and HVPG in the TJLB group (Spearman’s rho − 0.58) (p = 0.002). There was no statistically significant difference in minor complication between the two procedures. Only one patient who underwent PLB developed major complication and none of TLJB procedure had any major complication.

Conclusion Yield of tissue and complication rates are comparable in TJLB and PLB groups. Yield of tissue in TJLB have intermediate but significant negative correlation with HVPG.

Publication History

Article published online:
10 September 2020

© 2020. Indian Society of Gastrointestinal and Abdominal Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India