Semin Reprod Med 2020; 38(02/03): 089-107
DOI: 10.1055/s-0040-1718920
Review Article

Epidemiology of Adenomyosis

1  Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan
,
Stacey A. Missmer
1  Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan
2  Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan
3  Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
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Funding This work was supported by the National Institute of Nursing Research (grant R00NR017191 to K.U.) and Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant R01HD094842 to S.A.M.) of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Abstract

Adenomyosis, characterized by the presence of endometrial glands and stroma within the myometrium, can have a substantial impact on the quality of women's lives. Despite this, the epidemiologic research on this condition lags considerably behind that of other noncancerous reproductive health conditions. The lack of progress and knowledge is due in part to the challenges in designing valid epidemiologic studies, since the diagnosis of adenomyosis historically has been limited to the examination of uterine specimens from hysterectomy. This review describes the available data on the frequency of this condition and the epidemiologic investigation thus far into the risk factors for disease—highlighting the methodologic and inference challenges primarily around study sample selection. We conclude with providing recommendations for approaches to future epidemiologic study that capitalize on the advancements in imaging technology to detect adenomyosis and provide a fuller picture of the occurrence and risk factors for disease.



Publikationsverlauf

Publikationsdatum:
26. Oktober 2020 (online)

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