Digestive Disease Interventions 2021; 05(01): 055-069
DOI: 10.1055/s-0040-1721785
Review Article

Multidisciplinary Management of Postoperative Pancreatic Fistula

Alexa Glencer
1   Department of Surgery, University of California San Francisco, San Francisco, California
,
Kim Kirkwood
1   Department of Surgery, University of California San Francisco, San Francisco, California
,
Adam Schwertner
2   Department of Radiology, University of California San Francisco, San Francisco, California
,
Cody Keller
3   Department of Surgery, Stanford University, Stanford, California
,
Mustafa Arain
4   Department of Gastroenterology, University of California San Francisco, San Francisco, California
,
Patrick Avila
4   Department of Gastroenterology, University of California San Francisco, San Francisco, California
,
David M. Hovsepian
5   Department of Radiology, Stanford University, Stanford, California
› Author Affiliations

Abstract

Postoperative pancreatic fistulas are complex, challenging problems that often take weeks, months, or longer to resolve. Multiple interventions may be required to achieve a successful outcome. As such, resolution typically involves a multidisciplinary approach by a team whose skills include abdominal imaging, specialized surgery, advanced endoscopy, and interventional radiology. Intensive resources and time are often required, which impacts both patients and their caregivers. While treatment(s) continue to improve, a primary goal of research efforts in this area is the prevention of this significant source of postoperative morbidity, mortality, and economic strain.



Publication History

Received: 08 September 2020

Accepted: 12 November 2020

Article published online:
17 February 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Ferrone CR, Pieretti-Vanmarcke R, Bloom JP. et al. Pancreatic ductal adenocarcinoma: long-term survival does not equal cure. Surgery 2012; 152 (03) (Suppl. 01) S43-S49
  • 2 Katz MH, Wang H, Fleming JB. et al. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol 2009; 16 (04) 836-847
  • 3 He J, Ahuja N, Makary MA. et al. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford) 2014; 16 (01) 83-90
  • 4 Cillo U, Fondevila C, Donadon M. et al. Surgery for cholangiocarcinoma. Liver Int 2019; 39 (01) (Suppl. 01) 143-155
  • 5 Marchegiani G, Mino-Kenudson M, Sahora K. et al. IPMN involving the main pancreatic duct: biology, epidemiology, and long-term outcomes following resection. Ann Surg 2015; 261 (05) 976-983
  • 6 Vallance AE, Young AL, Macutkiewicz C, Roberts KJ, Smith AM. Calculating the risk of a pancreatic fistula after a pancreaticoduodenectomy: a systematic review. HPB (Oxford) 2015; 17 (11) 1040-1048
  • 7 Callery MP, Pratt WB, Vollmer Jr CM. Prevention and management of pancreatic fistula. J Gastrointest Surg 2009; 13 (01) 163-173
  • 8 Schoellhammer HF, Fong Y, Gagandeep S. Techniques for prevention of pancreatic leak after pancreatectomy. Hepatobiliary Surg Nutr 2014; 3 (05) 276-287
  • 9 Halle-Smith JM, Vinuela E, Brown RM. et al. A comparative study of risk factors for pancreatic fistula after pancreatoduodenectomy or distal pancreatectomy. HPB (Oxford) 2017; 19 (08) 727-734
  • 10 Ansorge C, Regner S, Segersvärd R, Strömmer L. Early intraperitoneal metabolic changes and protease activation as indicators of pancreatic fistula after pancreaticoduodenectomy. Br J Surg 2012; 99 (01) 104-111
  • 11 Poon RT, Lo SH, Fong D, Fan ST, Wong J. Prevention of pancreatic anastomotic leakage after pancreaticoduodenectomy. Am J Surg 2002; 183 (01) 42-52
  • 12 Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006; 244 (01) 10-15
  • 13 Tanaka M, Fernández-Del Castillo C, Kamisawa T. et al. Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology 2017; 17 (05) 738-753
  • 14 Maggino L, Malleo G, Bassi C. et al. Decoding grade B pancreatic fistula: a clinical and economical analysis and subclassification proposal. Ann Surg 2019; 269 (06) 1146-1153
  • 15 Nappo G, Capretti GL, Petitti T. et al. The evolution of post-operative pancreatic fistula (POPF) classification: a single-center experience. Pancreatology 2019; 19 (03) 449-455
  • 16 Matsusue S, Takeda H, Nakamura Y, Nishimura S, Koizumi S. A prospective analysis of the factors influencing pancreaticojejunostomy performed using a single method, in 100 consecutive pancreaticoduodenectomies. Surg Today 1998; 28 (07) 719-726
  • 17 Ecker BL, McMillan MT, Allegrini V. et al. Risk factors and mitigation strategies for pancreatic fistula after distal pancreatectomy: analysis of 2026 resections from the International, Multi-institutional Distal Pancreatectomy Study Group. Ann Surg 2019; 269 (01) 143-149
  • 18 Roberts KJ, Hodson J, Mehrzad H. et al. A preoperative predictive score of pancreatic fistula following pancreatoduodenectomy. HPB (Oxford) 2014; 16 (07) 620-628
  • 19 Hashimoto Y, Traverso LW. After distal pancreatectomy pancreatic leakage from the stump of the pancreas may be due to drain failure or pancreatic ductal back pressure. J Gastrointest Surg 2012; 16 (05) 993-1003
  • 20 Goh BK, Tan YM, Chung YF. et al. Critical appraisal of 232 consecutive distal pancreatectomies with emphasis on risk factors, outcome, and management of the postoperative pancreatic fistula: a 21-year experience at a single institution. Arch Surg 2008; 143 (10) 956-965
  • 21 Lin JW, Cameron JL, Yeo CJ, Riall TS, Lillemoe KD. Risk factors and outcomes in postpancreaticoduodenectomy pancreaticocutaneous fistula. J Gastrointest Surg 2004; 8 (08) 951-959
  • 22 Yeh TS, Jan YY, Jeng LB. et al. Pancreaticojejunal anastomotic leak after pancreaticoduodenectomy--multivariate analysis of perioperative risk factors. J Surg Res 1997; 67 (02) 119-125
  • 23 Martin AN, Narayanan S, Turrentine FE, Bauer TW, Adams RB, Zaydfudim VM. Pancreatic duct size and gland texture are associated with pancreatic fistula after pancreaticoduodenectomy but not after distal pancreatectomy. PLoS One 2018; 13 (09) e0203841
  • 24 Hackert T, Klaiber U, Hinz U. et al. Sphincter of Oddi botulinum toxin injection to prevent pancreatic fistula after distal pancreatectomy. Surgery 2017; 161 (05) 1444-1450
  • 25 Renou C, Grandval P, Ville E, Laugier R. Endoscopic treatment of the main pancreatic duct: correlations among morphology, manometry, and clinical follow-up. Int J Pancreatol 2000; 27 (02) 143-149
  • 26 Czosnyka NM, Borgert AJ, Smith TJ. Pancreatic adenocarcinoma: effects of neoadjuvant therapy on post-pancreatectomy outcomes - an American College of Surgeons National Surgical Quality Improvement Program targeted variable review. HPB (Oxford) 2017; 19 (10) 927-932
  • 27 Zettervall SL, Ju T, Holzmacher JL, Rivas L, Lin PP, Vaziri K. Neoadjuvant radiation is associated with fistula formation following pancreaticoduodenectomy. J Gastrointest Surg 2018; 22 (06) 1026-1033
  • 28 Roberts KJ, Sutcliffe RP, Marudanayagam R. et al. Scoring system to predict pancreatic fistula after pancreaticoduodenectomy: a UK multicenter study. Ann Surg 2015; 261 (06) 1191-1197
  • 29 Callery MP, Pratt WB, Kent TS, Chaikof EL, Vollmer Jr CM. A prospectively validated clinical risk score accurately predicts pancreatic fistula after pancreatoduodenectomy. J Am Coll Surg 2013; 216 (01) 1-14
  • 30 Mungroop TH, van Rijssen LB, van Klaveren D. et al; Dutch Pancreatic Cancer Group. Alternative fistula risk score for pancreatoduodenectomy (a-FRS): design and international external validation. Ann Surg 2019; 269 (05) 937-943
  • 31 Lao M, Zhang X, Guo C. et al. External validation of alternative fistula risk score (a-FRS) for predicting pancreatic fistula after pancreatoduodenectomy. HPB (Oxford) 2020; 22 (01) 58-66
  • 32 Bassi C, Falconi M, Molinari E. et al. Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study. Ann Surg 2005; 242 (06) 767-771 , discussion 771–773
  • 33 Duffas JP, Suc B, Msika S. et al; French Associations for Research in Surgery. A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy. Am J Surg 2005; 189 (06) 720-729
  • 34 Dixon E, Fingerhut A, Bassi C, Sutherland F, McKay A. Meta-analysis of pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy: authors' comment (Br J Surg 2006; 93: 929-936). Br J Surg 2006; 93 (11) 1435
  • 35 Wente MN, Shrikhande SV, Müller MW. et al. Pancreaticojejunostomy versus pancreaticogastrostomy: systematic review and meta-analysis. Am J Surg 2007; 193 (02) 171-183
  • 36 Topal B, Fieuws S, Aerts R. et al; Belgian Section of Hepatobiliary and Pancreatic Surgery. Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial. Lancet Oncol 2013; 14 (07) 655-662
  • 37 Stojadinovic A, Brooks A, Hoos A, Jaques DP, Conlon KC, Brennan MF. An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma. J Am Coll Surg 2003; 196 (06) 954-964
  • 38 Rivas L, Zettervall SL, Ju T. et al. The effect of pancreaticojejunostomy technique on fistula formation following pancreaticoduodenectomy in the soft pancreas. J Gastrointest Surg 2019; 23 (11) 2211-2215
  • 39 Berger AC, Howard TJ, Kennedy EP. et al. Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg 2009; 208 (05) 738-747 , discussion 747–749
  • 40 Winter JM, Cameron JL, Campbell KA. et al. Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial. J Gastrointest Surg 2006; 10 (09) 1280-1290 , discussion 1290
  • 41 Dong Z, Xu J, Wang Z, Petrov MS. Stents for the prevention of pancreatic fistula following pancreaticoduodenectomy. Cochrane Database Syst Rev 2013; (06) CD008914
  • 42 Zhou Y, Yang C, Wang S, Chen J, Li B. Does external pancreatic duct stent decrease pancreatic fistula rate after pancreatic resection?: a meta-analysis. Pancreatology 2011; 11 (03) 362-370
  • 43 Patel K, Teta A, Sukharamwala P, Thoens J, Szuchmacher M, DeVito P. External pancreatic duct stent reduces pancreatic fistula: a meta-analysis and systematic review. Int J Surg 2014; 12 (08) 827-832
  • 44 Pessaux P, Sauvanet A, Mariette C. et al; Fédération de Recherche en Chirurgie (French). External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy: prospective multicenter randomized trial. Ann Surg 2011; 253 (05) 879-885
  • 45 Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M. Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg 2012; 99 (04) 524-531
  • 46 Lee SE, Ahn YJ, Jang JY, Kim SW. Prospective randomized pilot trial comparing closed suction drainage and gravity drainage of the pancreatic duct in pancreaticojejunostomy. J Hepatobiliary Pancreat Surg 2009; 16 (06) 837-843
  • 47 Sunagawa M, Yokoyama Y, Yamaguchi J. et al. Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy?. Pancreatology 2019; 19 (04) 602-607
  • 48 Andrianello S, Marchegiani G, Malleo G. et al. Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis: a single-center, phase 3, randomized clinical trial. JAMA Surg 2020; 155 (04) 313-321
  • 49 Frozanpor F, Lundell L, Segersvärd R, Arnelo U. The effect of prophylactic transpapillary pancreatic stent insertion on clinically significant leak rate following distal pancreatectomy: results of a prospective controlled clinical trial. Ann Surg 2012; 255 (06) 1032-1036
  • 50 Diener MK, Seiler CM, Rossion I. et al. Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet 2011; 377 (9776): 1514-1522
  • 51 Knaebel HP, Diener MK, Wente MN, Büchler MW, Seiler CM. Systematic review and meta-analysis of technique for closure of the pancreatic remnant after distal pancreatectomy. Br J Surg 2005; 92 (05) 539-546
  • 52 Zhou W, Lv R, Wang X, Mou Y, Cai X, Herr I. Stapler vs suture closure of pancreatic remnant after distal pancreatectomy: a meta-analysis. Am J Surg 2010; 200 (04) 529-536
  • 53 Zhang H, Zhu F, Shen M. et al. Systematic review and meta-analysis comparing three techniques for pancreatic remnant closure following distal pancreatectomy. Br J Surg 2015; 102 (01) 4-15
  • 54 Nakamura M, Ueda J, Kohno H. et al. Prolonged peri-firing compression with a linear stapler prevents pancreatic fistula in laparoscopic distal pancreatectomy. Surg Endosc 2011; 25 (03) 867-871
  • 55 Cheng Y, Ye M, Xiong X. et al. Fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery. Cochrane Database Syst Rev 2016; 2: CD009621
  • 56 Ferrone CR, Warshaw AL, Rattner DW. et al. Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg 2008; 12 (10) 1691-1697 , discussion 1697–1698
  • 57 Johnston FM, Cavataio A, Strasberg SM. et al. The effect of mesh reinforcement of a stapled transection line on the rate of pancreatic occlusion failure after distal pancreatectomy: review of a single institution's experience. HPB (Oxford) 2009; 11 (01) 25-31
  • 58 Ceppa EP, McCurdy RM, Becerra DC. et al. Does pancreatic stump closure method influence distal pancreatectomy outcomes?. J Gastrointest Surg 2015; 19 (08) 1449-1456
  • 59 Hamilton NA, Porembka MR, Johnston FM. et al. Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. Ann Surg 2012; 255 (06) 1037-1042
  • 60 Jang JY, Shin YC, Han Y. et al. Effect of polyglycolic acid mesh for prevention of pancreatic fistula following distal pancreatectomy: a randomized clinical trial. JAMA Surg 2017; 152 (02) 150-155
  • 61 Hassenpflug M, Hinz U, Strobel O. et al. Teres ligament patch reduces relevant morbidity after distal pancreatectomy (the DISCOVER Randomized Controlled Trial). Ann Surg 2016; 264 (05) 723-730
  • 62 Carter TI, Fong ZV, Hyslop T. et al. A dual-institution randomized controlled trial of remnant closure after distal pancreatectomy: does the addition of a falciform patch and fibrin glue improve outcomes?. J Gastrointest Surg 2013; 17 (01) 102-109
  • 63 Bilimoria MM, Cormier JN, Mun Y, Lee JE, Evans DB, Pisters PW. Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligation. Br J Surg 2003; 90 (02) 190-196
  • 64 Kawai M, Tani M, Terasawa H. et al. Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg 2006; 244 (01) 1-7
  • 65 Van Buren II G, Bloomston M, Hughes SJ. et al. A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg 2014; 259 (04) 605-612
  • 66 Correa-Gallego C, Brennan MF, Dʼangelica M. et al. Operative drainage following pancreatic resection: analysis of 1122 patients resected over 5 years at a single institution. Ann Surg 2013; 258 (06) 1051-1058
  • 67 Molinari E, Bassi C, Salvia R. et al. Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients. Ann Surg 2007; 246 (02) 281-287
  • 68 Ven Fong Z, Correa-Gallego C, Ferrone CR. et al. Early drain removal--the middle ground between the drain versus no drain debate in patients undergoing pancreaticoduodenectomy: a prospective validation study. Ann Surg 2015; 262 (02) 378-383
  • 69 Daniel F, Tamim H, Hosni M, Ibrahim F, Mailhac A, Jamali F. Validation of day 1 drain fluid amylase level for prediction of clinically relevant fistula after distal pancreatectomy using the NSQIP database. Surgery 2019; 165 (02) 315-322
  • 70 Winter JM, Cameron JL, Yeo CJ. et al. Biochemical markers predict morbidity and mortality after pancreaticoduodenectomy. J Am Coll Surg 2007; 204 (05) 1029-1036 , discussion 1037–1038
  • 71 Okabayashi T, Kobayashi M, Nishimori I, Sugimoto T, Onishi S, Hanazaki K. Risk factors, predictors and prevention of pancreatic fistula formation after pancreatoduodenectomy. J Hepatobiliary Pancreat Surg 2007; 14 (06) 557-563
  • 72 Cloyd JM, Kastenberg ZJ, Visser BC, Poultsides GA, Norton JA. Postoperative serum amylase predicts pancreatic fistula formation following pancreaticoduodenectomy. J Gastrointest Surg 2014; 18 (02) 348-353
  • 73 de Reuver PR, Gundara J, Hugh TJ, Samra JS, Mittal A. Intra-operative amylase in peri-pancreatic fluid independently predicts for pancreatic fistula post pancreaticoduodectomy. HPB (Oxford) 2016; 18 (07) 608-614
  • 74 Nahm CB, de Reuver PR, Hugh TJ. et al. Intra-operative amylase concentration in peri-pancreatic fluid predicts pancreatic fistula after distal pancreatectomy. J Gastrointest Surg 2017; 21 (06) 1031-1037
  • 75 Büchler M, Friess H, Klempa I. et al. Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg 1992; 163 (01) 125-130 , discussion 130–131
  • 76 Droeser RA, Jeanmonod P, Schuld J, Moussavian MR, Schilling MK, Kollmar O. Octreotide prophylaxis is not beneficial for biochemical activity and clinical severity of postoperative pancreatic fistula after pancreatic surgery. Dig Surg 2012; 29 (06) 484-491
  • 77 Gurusamy KS, Koti R, Fusai G, Davidson BR. Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev 2013; (04) CD008370
  • 78 Lowy AM, Lee JE, Pisters PW. et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg 1997; 226 (05) 632-641
  • 79 Yeo CJ, Cameron JL, Lillemoe KD. et al. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Ann Surg 2000; 232 (03) 419-429
  • 80 Allen PJ, Gönen M, Brennan MF. et al. Pasireotide for postoperative pancreatic fistula. N Engl J Med 2014; 370 (21) 2014-2022
  • 81 Elliott IA, Dann AM, Ghukasyan R. et al. Pasireotide does not prevent postoperative pancreatic fistula: a prospective study. HPB (Oxford) 2018; 20 (05) 418-422
  • 82 Kunstman JW, Goldman DA, Gönen M. et al. Outcomes after pancreatectomy with routine pasireotide use. J Am Coll Surg 2019; 228 (02) 161-170.e2
  • 83 Abbott DE, Sutton JM, Jernigan PL. et al. Prophylactic pasireotide administration following pancreatic resection reduces cost while improving outcomes. J Surg Oncol 2016; 113 (07) 784-788
  • 84 Goyert N, Eeson G, Kagedan DJ. et al. Pasireotide for the prevention of pancreatic fistula following pancreaticoduodenectomy: a cost-effectiveness analysis. Ann Surg 2017; 265 (01) 2-10
  • 85 Ma LW, Dominguez-Rosado I, Gennarelli RL. et al. The cost of postoperative pancreatic fistula versus the cost of pasireotide: results from a prospective randomized trial. Ann Surg 2017; 265 (01) 11-16
  • 86 Denbo JW, Slack RS, Bruno M. et al. selective perioperative administration of pasireotide is more cost-effective than routine administration for pancreatic fistula prophylaxis. J Gastrointest Surg 2017; 21 (04) 636-646
  • 87 Hashimoto M, Koga M, Ishiyama K. et al. CT features of pancreatic fistula after pancreaticoduodenectomy. AJR Am J Roentgenol 2007; 188 (04) W323-W327
  • 88 Gervais DA, Fernandez-del Castillo C, O'Neill MJ, Hahn PF, Mueller PR. Complications after pancreatoduodenectomy: imaging and imaging-guided interventional procedures. Radiographics 2001; 21 (03) 673-690
  • 89 Faccioli N, Foti G, Molinari E. et al. Role of fistulography in evaluating pancreatic fistula after pancreaticoduodenectomy. Br J Radiol 2012; 85 (1011): 219-224
  • 90 Cronin CG, Gervais DA, Castillo CF, Mueller PR, Arellano RS. Interventional radiology in the management of abdominal collections after distal pancreatectomy: a retrospective review. AJR Am J Roentgenol 2011; 197 (01) 241-246
  • 91 Putzer D, Schullian P, Stättner S. et al. Interventional management after complicated pancreatic surgery. Eur Surg 2019; 51 (03) 105-113
  • 92 Popat B, Thakkar D, Deshmukh H, Rathod K. Percutaneous transhepatic biliary drainage in the management of post-surgical biliary leaks. Indian J Surg 2017; 79 (01) 24-28
  • 93 Alexakis N, Sutton R, Neoptolemos JP. Surgical treatment of pancreatic fistula. Dig Surg 2004; 21 (04) 262-274
  • 94 Devière J, Bueso H, Baize M. et al. Complete disruption of the main pancreatic duct: endoscopic management. Gastrointest Endosc 1995; 42 (05) 445-451
  • 95 Bradley III EL, Young Jr PR, Chang MC. et al. Diagnosis and initial management of blunt pancreatic trauma: guidelines from a multiinstitutional review. Ann Surg 1998; 227 (06) 861-869
  • 96 Shah RJ, Smolkin M, Yen R. et al. A multicenter, U.S. experience of single-balloon, double-balloon, and rotational overtube-assisted enteroscopy ERCP in patients with surgically altered pancreaticobiliary anatomy (with video). Gastrointest Endosc 2013; 77 (04) 593-600
  • 97 Chahal P, Baron TH, Topazian MD, Petersen BT, Levy MJ, Gostout CJ. Endoscopic retrograde cholangiopancreatography in post-Whipple patients. Endoscopy 2006; 38 (12) 1241-1245
  • 98 Chen YI, Levy MJ, Moreels TG. et al. An international multicenter study comparing EUS-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography after Whipple surgery. Gastrointest Endosc 2017; 85 (01) 170-177
  • 99 Yane K, Katanuma A, Osanai M. et al. Successful removal of a pancreatic duct stone in a patient with Whipple resection, using a short single-balloon enteroscope with a transparent hood. Endoscopy 2014; 46 (1, Suppl 1 UCTN): E86-E87
  • 100 Tarnasky P, Cunningham J, Cotton P. et al. Pancreatic sphincter hypertension increases the risk of post-ERCP pancreatitis. Endoscopy 1997; 29 (04) 252-257
  • 101 Kozarek RA, Ball TJ, Patterson DJ, Brandabur JJ, Traverso LW, Raltz S. Endoscopic pancreatic duct sphincterotomy: indications, technique, and analysis of results. Gastrointest Endosc 1994; 40 (05) 592-598
  • 102 Saeed ZA, Ramirez FC, Hepps KS. Endoscopic stent placement for internal and external pancreatic fistulas. Gastroenterology 1993; 105 (04) 1213-1217
  • 103 Telford JJ, Farrell JJ, Saltzman JR. et al. Pancreatic stent placement for duct disruption. Gastrointest Endosc 2002; 56 (01) 18-24
  • 104 Somogyi L, Chuttani R, Croffie J. et al. Biliary and pancreatic stents. Gastrointest Endosc 2006; 63 (07) 910-919
  • 105 Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA. Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc 1996; 44 (03) 268-275
  • 106 Freeman ML, Overby C, Qi D. Pancreatic stent insertion: consequences of failure and results of a modified technique to maximize success. Gastrointest Endosc 2004; 59 (01) 8-14
  • 107 Freeman ML. Complications of endoscopic retrograde cholangiopancreatography: avoidance and management. Gastrointest Endosc Clin N Am 2012; 22 (03) 567-586
  • 108 Varadarajulu S, Wilcox CM, Christein JD. EUS-guided therapy for management of peripancreatic fluid collections after distal pancreatectomy in 20 consecutive patients. Gastrointest Endosc 2011; 74 (02) 418-423
  • 109 Jürgensen C, Distler M, Arlt A. et al. EUS-guided drainage in the management of postoperative pancreatic leaks and fistulas (with video). Gastrointest Endosc 2019; 89 (02) 311-319.e1
  • 110 Muthusamy VR, Chandrasekhara V, Acosta RD. et al; ASGE Standards of Practice Committee. The role of endoscopy in the diagnosis and treatment of inflammatory pancreatic fluid collections. Gastrointest Endosc 2016; 83 (03) 481-488
  • 111 Storm AC, Levy MJ, Kaura K. et al. Acute and early EUS-guided transmural drainage of symptomatic postoperative fluid collections. Gastrointest Endosc 2020; 91 (05) 1085-1091.e1
  • 112 Siddiqui AA, Kowalski TE, Loren DE. et al. Fully covered self-expanding metal stents versus lumen-apposing fully covered self-expanding metal stent versus plastic stents for endoscopic drainage of pancreatic walled-off necrosis: clinical outcomes and success. Gastrointest Endosc 2017; 85 (04) 758-765
  • 113 Ahmad W, Fehmi SA, Savides TJ, Anand G, Chang MA, Kwong WT. Protocol of early lumen apposing metal stent removal for pseudocysts and walled off necrosis avoids bleeding complications. Scand J Gastroenterol 2020; 55 (02) 242-247
  • 114 Haseeb A, Abu Dayyeh BK, Levy MJ. et al. Endoscopic ultrasound-guided treatment of pancreaticocutaneous fistulas. ACG Case Rep J 2016; 3 (04) e105
  • 115 Irani S, Gluck M, Ross A. et al. Resolving external pancreatic fistulas in patients with disconnected pancreatic duct syndrome: using rendezvous techniques to avoid surgery (with video). Gastrointest Endosc 2012; 76 (03) 586-93.e1 , 3
  • 116 Nentwich MF, El Gammal AT, Lemcke T. et al. Salvage completion pancreatectomies as damage control for post-pancreatic surgery complications: a single-center retrospective analysis. World J Surg 2015; 39 (06) 1550-1556
  • 117 Kawakatsu S, Kaneoka Y, Maeda A, Fukami Y. Salvage anastomosis for postoperative chronic pancreatic fistula. Updates Surg 2016; 68 (04) 413-417
  • 118 Nair RR, Lowy AM, McIntyre B, Sussman JJ, Matthews JB, Ahmad SA. Fistulojejunostomy for the management of refractory pancreatic fistula. Surgery 2007; 142 (04) 636-642 , discussion 642.e1
  • 119 Casadei R, Bassi F, Calculli L, Zanini N, Greco VM, Minni F. Report of three cases of chronic pancreatic fistulas treated with prolamine as a sclerosing substance following pancreatic resection. JOP 2006; 7 (01) 41-46
  • 120 Avalos-González J, Portilla-deBuen E, Leal-Cortés CA. et al. Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant. World J Gastroenterol 2010; 16 (22) 2793-2800
  • 121 Wu X, Ren J, Gu G. et al. Autologous platelet rich fibrin glue for sealing of low-output enterocutaneous fistulas: an observational cohort study. Surgery 2014; 155 (03) 434-441
  • 122 Cambj Sapunar L, Sekovski B, Matić D, Tripković A, Grandić L, Družijanić N. Percutaneous embolization of persistent low-output enterocutaneous fistulas. Eur Radiol 2012; 22 (09) 1991-1997
  • 123 Lyon JW, Hodde JP, Hucks D, Changkuon DI. First experience with the use of a collagen fistula plug to treat enterocutaneous fistulas. J Vasc Interv Radiol 2013; 24 (10) 1559-1565
  • 124 Changala M, Laberge J, Kerlan R, Taylor A, Arain M, Kirkwood K. Managing refractory postoperative fistulas as chronic wounds using video-assisted hydrodebridement (VAHD). J Gastrointest Surg 2019; 23 (03) 608-612