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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2021; 40(02): e186-e189
DOI: 10.1055/s-0040-1722245
Case Report | Relato de Caso

Pleomorphic Xanthoastrocytoma with Oligodendroglioma-Like Areas with Negative 1p19q Co-Deletion

Deepa Goel 
1   Department of Pathology, Artemis Hospitals, Gurugram, Haryana, India
,
Shobhna Sharma 
1   Department of Pathology, Artemis Hospitals, Gurugram, Haryana, India
,
Aditya Gupta
2   Department of Neurosurgery, Artemis Hospitals, Gurugram, Haryana, India
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Abstract

The most common mixed glioma encountered in routine surgical practice is oligoastrocytoma (OA); however, its is currently considered a vanishing entity. The 2016 classification of the World Health Organization (WHO) discourages the diagnosis of tumors as mixed glioma. The recommendations are that diffuse gliomas, including those with mixed or ambiguous histological features, should be subjected to molecular testing. Dual-genotype OAs are not yet a distinct entity or variant in the classification. We report a case of mixed glioma: a pleomorphic xanthoastrocytoma (PXA) mixed with an oligodendroglioma. The immunohistochemistry (IHC) pattern of isocitrate dehydrogenase 1 (IDH1) negativity with retained nuclear expression of the alpha-thalassemia x-linked intellectual disability syndrome (ATRX) protein, and 1p19q co-deletion negativity in both the components enabled its identification as a mixed glioma rather than a collision tumor. To the best of our knowledge, the case herein presented is the fourth case of PXA with oligodendroglioma. Out of the other three reported cases, only one was of a collision tumor with a dual genotype, and the other two showed similar molecular signatures in both components. The present article discusses the histological, immunohistochemical and molecular features of the aforementioned case.

Keywords

pleomorphic xanthoastrocytoma - mixed glioma - composite glioma - oligodendroglioma - 1p19q

Contribution of the Authors

1 Deepa Goel - data analysis, manuscript preparation, manuscript editing.


2 - literature search, manuscript review.


3 - manuscript review.


Guarantor - Dr. Deepa Goel.




Publication History

Received: 13 August 2020

Accepted: 16 November 2020

Article published online:
18 January 2021

© 2021. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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