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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2022; 26(01): e158-e166
DOI: 10.1055/s-0040-1722250
Systematic Review

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Natalia Ferrazoli 
1   Postgraduate Program in Health, Interdisciplinary Practice and Rehabilitation, Universidade Estadual de Campinas, Campinas, SP, Brazil
2   Clinica Ouvire, Campinas, SP, Brazil
,
Caroline Donadon 
2   Clinica Ouvire, Campinas, SP, Brazil
3   Postgraduate Program in Child and Adolescent Health, Universidade Estadual de Campinas, Campinas, SP, Brazil
,
Adriano Rezende 
2   Clinica Ouvire, Campinas, SP, Brazil
,
Piotr H. Skarzynski 
4   Department of Teleaudiology and Hearing Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, Warsaw/Kajetany, Poland
5   Department of Heart Failure and Cardiac Rehabilitation, Institute of Sensory Organs, Warsaw, Poland
,
Milaine Dominici Sanfins 
2   Clinica Ouvire, Campinas, SP, Brazil
6   Centro de Eletrofisiologia e Neuroaudiologia Avançada, Sao Paulo, SP, Brazil
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Abstract

Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination.

Objective To review the literature on the application and findings of P300 as an indicator of PD.

Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments.

Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.

Keywords

Parkinson disease - attention - P300 - event-related potential - elderly


Publication History

Received: 12 September 2020

Accepted: 08 November 2020

Article published online:
29 March 2021

© 2021. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Macuglia GR, Rieder CRM, Almeida RMM. Executive Functions in Parkinson's Disease: Systematic Review of Literature. PSICO 2012; 43 (04) 552-561
    Google Scholar
  • 2 Robbins TW, Cools R. Cognitive deficits in Parkinson's disease: a cognitive neuroscience perspective. Mov Disord 2014; 29 (05) 597-607
    CrossrefPubMedGoogle Scholar
  • 3 Dirnberger G, Jahanshahi M. Executive dysfunction in Parkinson's disease: a review. J Neuropsychol 2013; 7 (02) 193-224
    CrossrefPubMedGoogle Scholar
  • 4 Yilmaz FT, Özkaynak SS, Barçin E. Contribution of auditory P300 test to the diagnosis of mild cognitive impairment in Parkinson's disease. Neurol Sci 2017; 38 (12) 2103-2109
    CrossrefPubMedGoogle Scholar
  • 5 Kraus N, MCGee T. Auditory event related potentials. Handbook of Clinical Audiology. Baltimore: Williams & Wilkins; 1994
    Google Scholar
  • 6 Solís-Vivanco R, Rodríguez-Violante M, Rodríguez-Agudelo Y, Schilmann A, Rodríguez-Ortiz U, Ricardo-Garcell J. The P3a wave: A reliable neurophysiological measure of Parkinson's disease duration and severity. Clin Neurophysiol 2015; 126 (11) 2142-2149
    CrossrefPubMedGoogle Scholar
  • 7 Cavanagh JF, Kumar P, Mueller AA, Richardson SP, Mueen A. Diminished EEG habituation to novel events effectively classifies Parkinson's patients. Clin Neurophysiol 2018; 129 (02) 409-418
    CrossrefPubMedGoogle Scholar
  • 8 Lei J, Conradi N, Abel C. et al. Cognitive effects of rhythmic auditory stimulation in Parkinson's disease: A P300 study. Brain Res 2019; 1716: 70-79
    CrossrefPubMedGoogle Scholar
  • 9 Silva Lopes Md, Souza Melo Ad, Nóbrega AC. Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson's disease in older patients. Arq Neuropsiquiatr 2014; 72 (04) 296-300
    CrossrefPubMedGoogle Scholar
  • 10 Sarikaya S, Yoldas TK, Yavasoglu NG. Evaluation of cognitive functions in Parkinson's patients without dementia with auditory event related potential (P300). Dusunen Adam 2014; 27 (02) 132-137
    Google Scholar
  • 11 Maidan I, Fahoum F, Shustak S. et al. Changes in event-related potentials during dual task walking in aging and Parkinson's disease. Clin Neurophysiol 2019; 130 (02) 224-230
    CrossrefPubMedGoogle Scholar
  • 12 Pauletti C, Mannarelli D, Locuratolo N, Currà A, Marinelli L, Fattapposta F. Central fatigue and attentional processing in Parkinson's disease: An event-related potentials study. Clin Neurophysiol 2019; 130 (05) 692-700
    CrossrefPubMedGoogle Scholar
  • 13 Solís-Vivanco R, Ricardo-Garcell J, Rodríguez-Camacho M. et al. Involuntary attention impairment in early Parkinson's disease: an event-related potential study. Neurosci Lett 2011; 495 (02) 144-149
    CrossrefPubMedGoogle Scholar
  • 14 Tang H, Huang J, Nie K. et al. Cognitive profile of Parkinson's disease patients: a comparative study between early-onset and late-onset Parkinson's disease. Int J Neurosci 2016; 126 (03) 227-234
    CrossrefPubMedGoogle Scholar
  • 15 Tokic K, Titlic M, Beganovic-Petrovic A, Suljic E, Romac R, Silic S. P300 Wave Changes in Patients with Parkinson's Disease. Med Arh 2016; 70 (06) 453-456
    CrossrefPubMedGoogle Scholar
  • 16 Naskar S, Sood SK, Goyal V. Effect of acute deep brain stimulation of the subthalamic nucleus on auditory event-related potentials in Parkinson's disease. Parkinsonism Relat Disord 2010; 16 (04) 256-260
    CrossrefPubMedGoogle Scholar
  • 17 Kenangil G, Orken DN, Ur E, Forta H, Celik M. The relation of testosterone levels with fatigue and apathy in Parkinson’s disease. Clin Neurol Neurosurg 2009; 111: 412-414
    CrossrefPubMedGoogle Scholar
  • 18 Kluger BM, Pedersen KF, Tysnes OB, Ongre SO, Øygarden B, Herlofson K. Is fatigue associated with cognitive dysfunction in early Parkinson’s disease?. Parkinsonism Relat Disord 2017; 37: 87-91
    CrossrefPubMedGoogle Scholar
  • 19 Goldman JG, Stebbins GT, Leung V, Tilley BC, Goetz CG. Relationships among cognitive impairment, sleep, and fatigue in Parkinson’s disease using the MDS-UPDRS. Parkinsonism Relat Disord 2014; 20: 1135-1139
    CrossrefPubMedGoogle Scholar
  • 20 Homayoun H. Parkinson Disease. Ann Intern Med 2018; 169 (05) ITC33-ITC48
    CrossrefPubMedGoogle Scholar
  • 21 Mello MPB, Botelho ACG. Correlation of evaluation scales utilized at Parkinson's disease applied to physical therapy. Fisioter Mov 2010; 23: 121-127
    CrossrefGoogle Scholar
  • 22 Sohn YH, Kim GW, Huh K, Kim JS. Dopaminergic influences on the P300 abnormality in Parkinson's disease. J Neurol Sci 1998; 158: 83-87
    CrossrefPubMedGoogle Scholar
  • 23 Aarsland D, Kurz MW. The epidemiology of dementia associated with Parkinson's disease. Brain Pathol 2010; 20 (03) 633-639
    CrossrefPubMedGoogle Scholar
  • 24 Peavy GM. Mild cognitive deficits in Parkinson disease: where there is bradykinesia, there is bradyphrenia. Neurology 2010; 75 (12) 1038-1039
    CrossrefPubMedGoogle Scholar
  • 25 Mhyre TR, Boyd JT, Hamill RW, Maguire-Zeiss KA. Parkinson's disease. Subcell Biochem 2012; 65: 389-455
    CrossrefPubMedGoogle Scholar
  • 26 Katsarou Z, Bostantjopoulou S, Kimiskidis V, Rossopoulos E, Kazis A. Auditory event-related potentials in Parkinson's disease in relation to cognitive ability. Percept Mot Skills 2004; 98 (3 Pt 2): 1441-1448
    CrossrefPubMedGoogle Scholar
  • 27 Boot N, Baas M, van Gaal S, Cools R, De Dreu CKW. Creative cognition and dopaminergic modulation of fronto-striatal networks: Integrative review and research agenda. Neurosci Biobehav Rev 2017; 78: 13-23
    CrossrefPubMedGoogle Scholar
  • 28 Kalia LV, Lang AE. Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD. Nat Rev Neurol 2016; 12 (02) 65-66
    CrossrefPubMedGoogle Scholar
  • 29 Woollacott M, Shumway-Cook A. Attention and the control of posture and gait: a review of an emerging area of research. Gait Posture 2002; 16 (01) 1-14
    CrossrefPubMedGoogle Scholar
  • 30 Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord 2008; 23 (03) 329-342 , quiz 472
    CrossrefPubMedGoogle Scholar
  • 31 Johnson Jr R. On the neural generators of the P300 component of the event-related potential. Psychophysiology 1993; 30 (01) 90-97
    CrossrefPubMedGoogle Scholar
  • 32 Thaut C, Rice R. Rhythmic Auditory Stimulation (RAS). In: Thaut M, Hoemberg V. ed. Handbook of Neurologic Music Therapy. Oxford: Oxford University Press; 2014: 94-105
    Google Scholar
  • 33 Bella SD, Benoit CE, Farrugia N, Schwartze M, Kotz SA. Effects of musically cued gait training in Parkinson's disease: beyond a motor benefit. Ann N Y Acad Sci 2015; 1337: 77-85
    CrossrefPubMedGoogle Scholar
  • 34 Arias P, Cudeiro J. Effects of rhythmic sensory stimulation (auditory, visual) on gait in Parkinson's disease patients. Exp Brain Res 2008; 186 (04) 589-601
    CrossrefPubMedGoogle Scholar
  • 35 van der Steen MC, Schwartze M, Kotz SA, Keller PE. Modeling effects of cerebellar and basal ganglia lesions on adaptation and anticipation during sensorimotor synchronization. Ann N Y Acad Sci 2015; 1337: 101-110
    CrossrefPubMedGoogle Scholar
  • 36 Nombela C, Hughes LE, Owen AM, Grahn JA. Into the groove: can rhythm influence Parkinson's disease?. Neurosci Biobehav Rev 2013; 37 (10 Pt 2): 2564-2570
    CrossrefPubMedGoogle Scholar
  • 37 Friedman JH, Brown RG, Comella C. et al; Working Group on Fatigue in Parkinson's Disease. Fatigue in Parkinson's disease: a review. Mov Disord 2007; 22 (03) 297-308
    CrossrefPubMedGoogle Scholar
  • 38 Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sci 2000; 179 ((S 1-2)): 34-42
    CrossrefPubMedGoogle Scholar
  • 39 Holtzer R, Mahoney JR, Izzetoglu M, Wang C, England S, Verghese J. Online fronto-cortical control of simple and attention-demanding locomotion in humans. Neuroimage 2015; 112: 152-159
    CrossrefPubMedGoogle Scholar
  • 40 Metzger FG, Ehlis AC, Haeussinger FB. et al. Functional brain imaging of walking while talking - An fNIRS study. Neuroscience 2017; 343: 85-93
    CrossrefPubMedGoogle Scholar
  • 41 Mirelman A, Maidan I, Bernad-Elazari H, Shustack S, Giladi N, Hausdorff JM. Effects of aging on prefrontal brain activation during challenging walking conditions. Brain Cogn 2017; 115: 41-46
    CrossrefPubMedGoogle Scholar
  • 42 Maidan I, Nieuwhof F, Bernad-Elazari H. et al. The Role of the Frontal Lobe in Complex Walking Among Patients With Parkinson's Disease and Healthy Older Adults: An fNIRS Study. Neurorehabil Neural Repair 2016; 30 (10) 963-971
    CrossrefPubMedGoogle Scholar
  • 43 Zhuang X, Mazzoni P, Kang UJ. The role of neuroplasticity in dopaminergic therapy for Parkinson disease. Nat Rev Neurol 2013; 9 (05) 248-256
    CrossrefPubMedGoogle Scholar
  • 44 Deuschl G, Schade-Brittinger C, Krack P. et al; German Parkinson Study Group, Neurostimulation Section. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006; 355 (09) 896-908
    CrossrefPubMedGoogle Scholar
  • 45 Barboza E Barbosa EN, Fichman HC. How is cognition in subthalamic nucleus deep brain stimulation Parkinson's disease patients?. Dement Neuropsychol 2019; 13 (04) 367-377
    CrossrefPubMedGoogle Scholar