Kutane Ablagerungsdermatosen – die Haut als Abfalleimer? Was muss der Kliniker wissen?

Zusammenfassung

Unter Ablagerungsdermatosen versteht man eine heterogene Gruppe von Erkrankungen, deren Gemeinsamkeit die Ablagerung endogener oder exogener Substanzen in der Dermis oder Subkutis ist. Oft liefern kutane Ablagerungen bei systemischen Erkrankungen einen entscheidenden diagnostischen Hinweis für den behandelnden Kliniker. Im folgenden Review wird eine Übersicht der Ablagerungsdermatosen anhand ihrer Einteilung, Klinik und Histopathologie erstellt.

Abstract

The cutaneous deposition disorders are a heterogeneous group of unrelated diseases sharing the common feature of depositions consisting of endogenous or exogenous substances in the dermis or subcutis. In many cases such cutaneous deposits provide the crucial hint for an underlying internal disease. The following review will issue an overview of the deposition disorders based on their classification, clinical appearance and histopathology.

• Literatur

• 1 Molina-Ruiz AM, Cerroni L, Kutzner H et al. Cutaneous deposits. The American Journal of dermatopathology 2014; 36: 1-48
• 2 Touart DM, Sau P. Cutaneous deposition diseases. Part II. Journal of the American Academy of Dermatology 1998; 39: 527-44; quiz 45-46
• 3 Touart DM, Sau P. Cutaneous deposition diseases. Part I. Journal of the American Academy of Dermatology 1998; 39: 149-71; quiz 72–74
• 4 Weaver J, Somani N, Bauer TW et al. Simple non-staining method to demonstrate urate crystals in formalin-fixed, paraffin-embedded skin biopsies. Journal of cutaneous pathology 2009; 36: 560-564
• 5 Ernst J, Saeger W, Linke RP et al. Praktische Hinweise zur Diagnose und Therapie generalisierter Amyloidosen. Dtsch Arztebl 1998; 95: A-2626-A-2636
• 6 Walsh JS, Fairley JA. Calcifying disorders of the skin. Journal of the American Academy of Dermatology 1995; 33: 693-706; quiz 07–10
• 7 Meier-Meitinger M, Adamietz B, Schulz-Wendtland R. Ehlers-Danlos syndrome and bilateral, dystrophic breast calcifications. Der Radiologe 2009; 49: 868-871
• 8 Rothe MJ, Grant-Kels JM, Rothfield NF. Extensive calcinosis cutis with systemic lupus erythematosus. Archives of dermatology 1990; 126: 1060-1063
• 9 Wilson PR. Porphyria cutanea tarda with cutaneous “scleroderma” and calcification. The Australasian journal of dermatology 1989; 30: 93-96
• 10 Oh DH, Eulau D, Tokugawa DA et al. Five cases of calciphylaxis and a review of the literature. Journal of the American Academy of Dermatology 1999; 40: 979-987
• 11 Hafner J, Nobbe S, Partsch H et al. Martorell hypertensive ischemic leg ulcer: a model of ischemic subcutaneous arteriolosclerosis. Archives of dermatology 2010; 146: 961-968
• 12 Mochel MC, Arakaki RY, Wang G et al. Cutaneous calciphylaxis: a retrospective histopathologic evaluation. The American Journal of dermatopathology 2013; 35: 582-586
• 13 Wollina U. Cutaneous calciphylaxis. Der Hautarzt 2010; 61: 1063-1071; quiz 72
• 14 Dominguez-Fernandez I, Goiriz R, Perez-Gala S et al. Calcinosis cutis following extravasation of calcium salts. JEADV 2008; 22: 505-506
• 15 Gfesser M, Worret WI, Hein R et al. Multiple primary osteoma cutis. Archives of dermatology 1998; 134: 641-643
• 16 Garg LN, Arora S, Gupta S et al. Pilomatricoma: Forget me not. Indian dermatology online journal 2011; 2: 75-77
• 17 Khandeparkar SG, Joshi A, Khande T et al. A rare case of giant soft tissue chondroma of the wrist: A cytopathological study with review of the literature. Journal of cytology/Indian Academy of Cytologists 2014; 31: 40-43
• 18 Ando K, Goto Y, Hirabayashi N et al. Cutaneous cartilaginous tumor. Dermatologic surgery 1995; 21: 339-341
• 19 Falasca GF. Metabolic diseases: gout. Clinics in dermatology 2006; 24: 498-508
• 20 Abels C, Karrer S, Landthaler M et al. Truss-induced macular amyloidosis. Der Hautarzt 2001; 52: 970-973
• 21 Chang YT, Liu HN, Wang WJ et al. A study of cytokeratin profiles in localized cutaneous amyloids. Archives of dermatological research 2004; 296: 83-88
• 22 Hintner H, Stossl H, Hopfl R et al. Amyloid K. Der Hautarzt 1988; 39: 419-425
• 23 Babilas P, Fiebig BS, Aslanidis C et al. Identification of an oncostatin M receptor mutation associated with familial primary cutaneous amyloidosis. The British journal of dermatology 2009; 161: 944-947
• 24 Schreml S, Weber BH, Schroder J et al. Familial primary localized cutaneous amyloidosis with an oncostatin M receptor-beta mutation, Pro694Leu. Clinical and experimental dermatology 2013; 38: 932-935
• 25 Breathnach SM. Amyloid and amyloidosis. Journal of the American Academy of Dermatology 1988; 18: 1-16
• 26 Rocken C, Ernst J, Hund E et al. Interdisciplinary guidelines for diagnosis and therapy of extracerebral amyloidosis: issued by the German Society of Amyloid Diseases e. V. (www.amyloid.de). Medizinische Klinik 2006; 101: 825-829
• 27 Besur S, Hou W, Schmeltzer P et al. Clinically important features of porphyrin and heme metabolism and the porphyrias. Metabolites 2014; 4: 977-1006
• 28 Horner ME, Alikhan A, Tintle S et al. Cutaneous porphyrias part I: epidemiology, pathogenesis, presentation, diagnosis, and histopathology. International journal of dermatology 2013; 52: 1464-1480
• 29 Murphy GM. The cutaneous porphyrias: a review. The British Photodermatology Group. The British journal of dermatology 1999; 140: 573-581
• 30 Dereure O. Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment. American journal of clinical dermatology 2001; 2: 253-262
• 31 Jacob CI. Tattoo-associated dermatoses: a case report and review of the literature. Dermatologic surgery 2002; 28: 962-965
• 32 Korner R, Pfohler C, Vogt T et al. Histopathology of body art revisited – analysis and discussion of 19 cases. JDDG 2013; 11: 1073-1080
• 33 Rubenstein MC, Martinelli PT, Bayer-Garner IB et al. Persistent cutaneous manifestations of hyperoxaluria after combined hepatorenal transplantation. Dermatology online journal 2004; 10: 10