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Digestive Disease Interventions 2021; 05(01): 009-016
DOI: 10.1055/s-0041-1726325
Review Article

Evaluation of Barrett's Esophagus

Trent Walradt
1   Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
,
Mohammad Bilal
2   Division of Gastroenterology, Beth Israel Deaconess Medical Center, Center for Advanced Endoscopy, Harvard Medical School, Boston, Massachusetts
,
Douglas K. Pleskow
2   Division of Gastroenterology, Beth Israel Deaconess Medical Center, Center for Advanced Endoscopy, Harvard Medical School, Boston, Massachusetts
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Abstract

Barrett's esophagus (BE) is the condition in which a metaplastic columnar epithelium that is predisposed to malignancy replaces the stratified squamous epithelium that normally lines the distal esophagus. BE develops as a consequence of chronic gastroesophageal reflux disease and predisposes to esophageal adenocarcinoma (EAC). Several societal guidelines recommend screening and surveillance for BE to reduce the risk of EAC and its related morbidity and mortality. Even among persons undergoing screening and surveillance, a substantial proportion of cases of EAC can be missed. Consequently, the armamentarium for the evaluation of BE has expanded rapidly over the past decade. In this article, we summarize the pathophysiology and diagnosis of BE. We also discuss the latest advancements in the evaluation of BE.

Keywords

Barrett's esophagus - esophageal adenocarcinoma - endoscopy


Publication History

Received: 09 October 2020

Accepted: 12 January 2021

Article published online:
18 March 2021

© 2021. Thieme. All rights reserved.

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