J Pediatr Genet 2021; 10(03): 194-204
DOI: 10.1055/s-0041-1731035
Review Article

Evaluation and Management of Early Onset Genetic Obesity in Childhood

Sonali Malhotra
1   Department of Pediatric Endocrinology, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, United States
Ramya Sivasubramanian
2   Division of Pediatric Nephrology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
3   Department of Medicine; Department of Pediatrics; Department of Surgery; Division of Endocrinology, Diabetes & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
› Author Affiliations
Funding None.


One in five children and adolescents in the United States are diagnosed with obesity and nearly 6% of them are being classified under the severe obesity category. With over 7% of severe obesity being attributed to genetic disorders, in this review we aim to focus on monogenic and syndromic obesity: its etiology, wide spectrum of clinical presentation, criticalness of early identification, and limited management options. Advanced genetic testing methods including microarray and whole genome sequencing are imperative to identify the spectrum of mutations and develop targeted treatment strategies including personalized multidisciplinary care, use of investigational drugs, and explore surgical options in this unique subset of severe pediatric obesity.


S.M. serves as a consultant to Rhythm Pharmaceuticals. R.S. has nothing to disclose. G.S. serves as a consultant to NovoNordisk and Rhythm Pharmaceuticals.

Publication History

Received: 18 February 2021

Accepted: 16 April 2021

Article published online:
03 July 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

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