Download PDF
CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2024; 43(01): e76-e80
DOI: 10.1055/s-0041-1731064
Case Report

Marginal Zone B-cell Lymphoma of the Gasserian Ganglion: Case Report and Review of the Literature

Linfoma de células B da zona marginal do gânglio de Gasser: Relato de caso e revisão da literatura
Ahmed Hegazy
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
,
Hieder Al-Shami 
2   Department of Neurosurgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
,
Biswas Arundhatai 
3   Department of Neurological Surgery, Albert Einstein College of Medicine of Yeshiva University/Montefiore Medical Center, Bronx, New York, United States
,
Mohammed Fathy
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
,
Ahmed M. Salah
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
,
Hashem Aboul-Ela
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
,
Mohamed F.M. Alsawy
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
,
Amr Mostafa Elkatatny
1   Department of Neurosurgery, Faculty of Medicine, Kasr Al-Ainy Medical College, Cairo, Egypt
› Author Affiliations
› Further Information
   Permissions and Reprints

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin's lymphoma that accounts for 4% of newly diagnosed central nervous system (CNS) tumors. Most primary lymphomas of the central nervous system are of the subtype of diffuse large B-cell lymphomas, which have highly aggressive behavior and may involve the brain, leptomeninges, eyes or spinal cord without evidence of systemic disease. Primary CNS lymphomas are very rare in immunocompetent patients, but their rates are increasing. So far, only 11 primary Gasser ganglion lymphomas have been reported, with an incidence of 2.5 cases per 30,000,000 inhabitants. However, B cell lymphomas of the marginal zone of the Gasserian ganglion have been very rarely reported. We report here a clinical presentation characteristic of B cell lymphoma of the marginal zone of the Gasser ganglion in an immunocompetent patient who was treated with surgery and radiotherapy, evolving with improvement of symptoms and without recurrence in 3 months of follow-up.

Resumo

O linfoma primário do sistema nervoso central (PCNSL, na sigla em inglês) é um subtipo raro de linfoma não-Hodgkin extranodal que representa 4% dos tumores recém-diagnosticados do sistema nervoso central (SNC). A maioria dos linfomas primários do sistema nervoso central é do subtipo dos linfomas difusos de grandes células B, que tem comportamento altamente agressivo e pode envolver cérebro, as leptomeninges, os olhos ou a medula espinhal sem evidências de doença sistêmica. Os linfomas primários do SNC são muito raros em pacientes imunocompetentes, mas suas taxas estão aumentando. Até o momento, apenas 11 linfomas primários do gânglio de Gasser foram relatados, com uma incidência de 2,5 casos por 30.000.000 de habitantes. No entanto, linfomas de células B da zona marginal do gânglio de Gasserian foram muito raramente relatados. Relatamos aqui uma apresentação clínica característica de um linfoma de células B da zona marginal do gânglio de Gasser em um paciente imunocompetente que foi tratado com cirurgia e radioterapia, evoluindo com melhora dos sintomas e sem recorrência em três meses de acompanhamento.

Keywords

facial pain - primary lymphoma of the central nervous system - trigeminal neuropathy

Palavras-chave

dor facial - linfoma primário do sistema nervoso central - neuropatia trigeminal


Publication History

Received: 18 May 2020

Accepted: 09 March 2021

Article published online:
07 January 2022

© 2022. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • References

  • 1 Roche PH, Lubrano VF, Noudel R. How I do it: epidural anterior petrosectomy. Acta Neurochir (Wien) 2011; 153 (06) 1161-1167
    Google Scholar
  • 2 Nakatomi H, Sasaki T, Kawamoto S, Fujimaki T, Furuya K, Kirino T. Primary cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: case report and review of the literature. Surg Neurol 1996; 46 (03) 272-278 , discussion 278–279
    Google Scholar
  • 3 Abdel Aziz KM, van Loveren HR. Primary lymphoma of Meckel's cave mimicking trigeminal schwannoma: case report. Neurosurgery 1999; 44 (04) 859-862 , discussion 862–863
    Google Scholar
  • 4 Kinoshita M, Izumoto S, Oshino S. et al. Primary malignant lymphoma of the trigeminal region treated with rapid infusion of high-dose MTX and radiation: case report and review of the literature. Surg Neurol 2003; 60 (04) 343-348 , discussion 348
    Google Scholar
  • 5 Bulsara KR, Kadri PA, Husain M, Al-Mefty O. Malignant lymphoma of the trigeminal region. Case illustration. J Neurooncol 2005; 73 (03) 279-280
    Google Scholar
  • 6 Iplikcioglu AC, Dinc C, Bikmaz K, Ozcan D. Primary lymphoma of the trigeminal nerve. Br J Neurosurg 2006; 20 (02) 103-105
    Google Scholar
  • 7 Akaza M, Tsunemi T, Sanjo N, Wakimoto H, Kobayashi D, Mizusawa H. [Malignant lymphoma presented as left trigeminal neuralgia]. Rinsho Shinkeigaku 2009; 49 (07) 432-436
    Google Scholar
  • 8 Yamahata H, Ishigami T, Hirahara K. et al. Primary T-cell/histiocyte-rich B-cell lymphoma arising in the trigeminal ganglion in a patient with rheumatoid arthritis. Brain Tumor Pathol 2012; 29 (01) 54-57
    Google Scholar
  • 9 Perera C, Fitt G, Kalnins R, Lee S, Gonzalvo A. Lymphoma of the trigeminal nerve--the need for histological diagnosis. Br J Neurosurg 2014; 28 (02) 278-280
    Google Scholar
  • 10 Jack AS, McDougall CM, Findlay JM. Primary lymphoma isolated to the trigeminal nerve. Can J Neurol Sci 2014; 41 (01) 103-105
    Google Scholar
  • 11 Ogiwara T, Horiuchi T, Sekiguchi N, Kakizawa Y, Hongo K. Primary Malignant Lymphoma of the Trigeminal Nerve: Case Report and Literature Review. World Neurosurg 2015; 84 (02) 592.e3-592.e7
    Google Scholar
  • 12 Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN. Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. J Clin Neurosci 2015; 22 (07) 1188-1190
    Google Scholar
  • 13 Kano H, Awan NR, Flannery TJ. et al. Stereotactic radiosurgery for patients with trigeminal neuralgia associated with petroclival meningiomas. Stereotact Funct Neurosurg 2011; 89 (01) 17-24
    Google Scholar
  • 14 Itoh T, Shimizu M, Kitami K. et al. Primary extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type in the CNS. Neuropathology 2001; 21 (03) 174-180
    Google Scholar
  • 15 Tu PH, Giannini C, Judkins AR. et al. Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma. J Clin Oncol 2005; 23 (24) 5718-5727
    Google Scholar
  • 16 Park I, Huh J, Kim JH, Lee S-W, Ryu M-H, Kang Y-K. Primary central nervous system marginal zone B-cell lymphoma of the Basal Ganglia mimicking low-grade glioma: a case report and review of the literature. Clin Lymphoma Myeloma 2008; 8 (05) 305-308
    Google Scholar
  • 17 Papanicolau-Sengos A, Wang-Rodriguez J, Wang HY. et al. Rare case of a primary non-dural central nervous system low grade B-cell lymphoma and literature review. Int J Clin Exp Pathol 2012; 5 (01) 89-95
    Google Scholar
  • 18 Aqil B, Rouah E, Verstovsek G. Primary CNS Marginal Zone Lymphoma: A Case Report and Review of the Literature. Open J Pathol 2013; 03 (02) 55-59
    Google Scholar
  • 19 Sebastián C, Vela AC, Figueroa R, Marín MÁ, Alfaro J. Primary intracranial mucosa-associated lymphoid tissue lymphoma. A report of two cases and literature review. Neuroradiol J 2014; 27 (04) 425-430
    Google Scholar
  • 20 Iwamoto FM, Abrey LE. Primary dural lymphomas: a review. Neurosurg Focus 2006; 21 (05) 1-5
    Google Scholar
  • 21 Ferreri AJ, Reni M, Foppoli M. et al; International Extranodal Lymphoma Study Group (IELSG). High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial. Lancet 2009; 374 (9700): 1512-1520
    Google Scholar
  • 22 Doolittle ND, Korfel A, Lubow MA. et al. Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma. Neurology 2013; 81 (01) 84-92
    Google Scholar