Semin Plast Surg 2021; 35(03): 145-152
DOI: 10.1055/s-0041-1731461
Review Article

Current Advances in Hypertrophic Scar and Keloid Management

Natasha Barone
1  Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada
,
Tyler Safran
2  Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, Canada
,
Joshua Vorstenbosch
2  Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, Canada
,
Peter G. Davison
2  Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, Canada
,
Sabrina Cugno
2  Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, Canada
,
Amanda M. Murphy
2  Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, Canada
3  Division of Plastic and Reconstructive Surgery, Jewish General Hospital, Montreal, Canada
› Author Affiliations

Abstract

Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury due to local fibroblast proliferation and collagen overproduction. This response occurs because of pathologic wound healing due to dysregulation in the inflammatory, proliferative, and/or remodeling phase. Patients with hypertrophic scars or keloids report reduced quality of life, physical status, and psychological health. Hypertrophic scars or keloids will develop in 30 to 90% of individuals, and despite their prevalence, treatment remains a challenge. Of the treatments currently available for hypertrophic scars and keloids few have been adequately supported by studies with appropriate experimental design. Here, we aim to review the available literature to provide up-to-date information on the etiology, epidemiology, histology, pathophysiology, prevention, and management options available for the treatment of hypertrophic scars and keloids and highlight areas where further research is required.



Publication History

Publication Date:
15 July 2021 (online)

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