Semin Plast Surg 2021; 35(03): 159-163
DOI: 10.1055/s-0041-1731462
Review Article

When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation

Christopher Conlon
1  Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Lauren Pupa
2  School of Medicine, Baylor College of Medicine, Houston, Texas
,
Edward M. Reece
1  Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
3  Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas
,
Carrie K. Chu
4  Department of Plastic Surgery, MD Anderson Cancer Center, University of Texas, Houston, Texas
,
Jessie Z. Yu
1  Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Joshua Vorstenbosch
5  Division of Plastic Surgery, McGill University, Montreal, Canada
,
Sebastian Winocour
1  Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
› Author Affiliations

Abstract

Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.



Publication History

Publication Date:
06 July 2021 (online)

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