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J Am Acad Audiol 2021; 32(10): 654-660
DOI: 10.1055/s-0041-1731700
Review Article
Special Issue on Hearing Therapeutics and Protective Therapies

From Bench to Booth: Examining Hair Cell Regeneration Through an Audiologist's Scope

Rebecca M. Lewis 
1   Whisper.ai, Department of Clinical Research, San Francisco, California
2   Georgetown University Medical Center, Department of Neuroscience, Washington, D.C.
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Abstract

Damage to auditory hair cells is a key feature of sensorineural hearing loss due to aging, noise exposure, or ototoxic drugs. Though hair cell loss is permanent in humans, research in bird species led to the discovery that analogous hair cells of the avian basilar papilla are able to regenerate after being damaged by ototoxic agents. Regeneration appears to occur through a combination of the mitotic expansion of a precursor population of supporting cells and direct transdifferentiation of supporting cells into functioning hair cells. This review will synthesize the relevant anatomy and pathophysiology of sensorineural hearing loss, the historical observations that led to the genesis of the hair cell regeneration field, and perspectives on initial human hair cell regeneration trials.

Keywords

hearing - auditory - cochlear implants

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Supplementary Material



Publication History

Received: 29 December 2020

Accepted: 20 May 2021

Article published online:
24 May 2022

© 2022. American Academy of Audiology. This article is published by Thieme.

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