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CC BY 4.0 · Rev Bras Ginecol Obstet 2021; 43(08): 595-599
DOI: 10.1055/s-0041-1733912
Original Article | Artigo Original
COVID-19/High Risk Pregnancy

COVID-19 in Pregnancy: Implication on Platelets and Blood Indices

COVID-19 na gravidez: implicações nas plaquetas e índices sanguíneos
Wassan Nori 
1   Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
,
Ban Hadi Hameed 
1   Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
,
Asmaa Rajih Thamir 
2   Department of Obstetrics and Gynecology, AL Yarmouk Teaching Hospital, Baghdad, Iraq
,
Amenah Fadhil 
1   Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
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Abstract

Objective To describe the hematological changes, the platelet indices in particular, in pregnant women with coronavirus disease 2019 (COVID-19) compared to healthy pregnant women.

Methods A retrospective case-control study conducted at the Al Yarmouk Teaching Hospital, in Baghdad, Iraq, involving 100 pregnant women, 50 with positive viral DNA for COVID-19 (case group), and 50 with negative results (control group); both groups were subjected to a thorough hematological evaluation.

Results Among the main hematological variables analyzed, the platelet indices, namely the mean platelet volume (MPV) and the platelet distribution width (PDW), showed statistically significant differences (MPV: 10.87 ± 66.92 fL for the case group versus 9.84 ± 1.2 fL for the control group; PDW: 14.82 ± 3.18 fL for the case group versus 13.3 ± 2.16 fL for the controls). The criterion value of the receiver operating characteristic (ROC) curve for PDW at a cutoff point of > 11.8 fL showed a weak diagnostic marker, while the MPV at a cutoff value of > 10.17 fL showed a good diagnostic marker.

Conclusion The MPV and PDW are significantly affected by the this viral infection, even in asymptomatic confirmed cases, and we recommend that both parameters be included in the diagnostic panel of this infection.

Resumo

Objetivo Descrever as alterações hematológicas, em particular os índices plaquetários em gestantes com doença coronavírus 2019 (COVID-19) em comparação com gestantes saudáveis.

Métodos Estudo caso-controle retrospectivo realizado no Hospital Universitário Al Yarmouk, em Bagdá, Iraque envolvendo 100 gestantes, 50 com DNA viral positivo para COVID-19 (grupo caso) e 50 com resultados negativos (grupo controle); ambos os grupos foram submetidos a uma avaliação hematológica completa.

Resultados Entre as principais variáveis hematológicas analisadas, os índices plaquetários, nomeadamente o volume plaquetário médio (VPM) e a largura de distribuição plaquetária (PDW), apresentaram diferenças estatisticamente significativas (VPM: 10,87 ± 66,92 fL para o grupo caso versus 9,84 ± 1.2 fL para o o grupo controle; PDW: 14,82 ± 3,18 fL para o grupo caso versus 13,3 ± 2,16 fL para os controles). O valor de critério da curva de característica de operação do receptor (ROC) para PDW em um ponto de corte de> 11,8 fL mostrou um marcador diagnóstico fraco, enquanto o do VPM em um valor de corte de> 10,17 fL mostrou um bom marcador de diagnóstico.

Conclusão O MPV e PDW são significativamente afetados por esta infecção viral, mesmo em casos confirmados assintomáticos, e recomendamos que ambos os parâmetros sejam incluídos no painel de diagnóstico desta infecção.

Keywords

COVID-19 - pregnancy - platelet indices - mean platelet volume - platelet distribution width

Palavras-chave

COVID-19 - gravidez - índices de plaquetas - volume médio de plaquetas - largura de distribuição de plaquetas

Contributions

All authors participated in the concept and design of the present study, in the analysis and interpretation of the data, in the draft or revision of the manuscript, and they have approved the manuscript as submitted. All authors are responsible for the reported research.




Publication History

Received: 23 November 2020

Accepted: 14 June 2021

Article published online:
21 September 2021

© 2021. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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