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DOI: 10.1055/s-0041-1736419
Safe Free Tissue Transfer in Patients Older than 90 Years

Abstract
Objective This study aimed to evaluate the safety of microvascular free tissue transfer in the elderly patient population.
Methods We performed a 20-year retrospective review at a tertiary care private practice of patients of ≥ 90 years of age who underwent microvascular free tissue transfer and had at least 6 months of follow-up. Similarly, we reviewed patients aged 70 to 89 years who underwent free tissue transfer between 2018 and 2020 as a control group. Records were examined for type of flap, defect site, pathology, and occurrence of complications.
Results Overall 77 patients of 90 years or older met the inclusion criteria and 77 sequential patients aged 70 to 89 years were identified to serve as a control group. The overall complication rate among patients of ≥ 90 years of age was 18%, with flap-related complications in 4% (two partial flap loss and one total loss). The mortality rate was 1.3%. All patients of ≥ 90 years of age undergoing osteocutaneous reconstruction for osteoradionecrosis experienced complications, but only one was a flap complication (partial loss). Among patients aged 70 to 89 years, the overall complication rate was also 18%, with flap-related complications in 4% (two complete flap failures and one partial loss). The mortality rate in the control group was 2.6%.
Conclusion Soft tissue free flaps are a safe option in the elderly patient population and should be offered to patients who are medically optimized prior to surgery, regardless of age. Osteocutaneous reconstruction for osteoradionecrosis must be undertaken with caution. This study reflects level of evidence 4.
Authors' Contributions
M.H.H. contributed to manuscript composition and literature review. A.G.V. contributed to manuscript composition and data analysis. A.R.E. contributed to literature review. Y.D. contributed to data collection and manuscript review.
Disclosures
The authors have no financial conflict to disclose. The work herein does not necessarily represent the views of the U.S. Army or Department of Defense.
Publication History
Received: 02 February 2021
Accepted: 31 May 2021
Article published online:
27 October 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Yang G, Chen B, Gao Y. et al. Forearm free skin flap transplantation. Zhonghua Yi Xue Za Zhi 1981; 61: 139-141
- 2 Suh JD, Sercarz JA, Abemayor E. et al. Analysis of outcome and complications in 400 cases of microvascular head and neck reconstruction. Arch Otolaryngol Head Neck Surg 2004; 130 (08) 962-966
- 3 Haughey BH, Wilson E, Kluwe L. et al. Free flap reconstruction of the head and neck: analysis of 241 cases. Otolaryngol Head Neck Surg 2001; 125 (01) 10-17
- 4 Spiegel JH, Polat JK. Microvascular flap reconstruction by otolaryngologists: prevalence, postoperative care, and monitoring techniques. Laryngoscope 2007; 117 (03) 485-490
- 5 Bui DT, Cordeiro PG, Hu QY, Disa JJ, Pusic A, Mehrara BJ. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 2007; 119 (07) 2092-2100
- 6 Rosenthal E, Carroll W, Dobbs M, Scott Magnuson J, Wax M, Peters G. Simplifying head and neck microvascular reconstruction. Head Neck 2004; 26 (11) 930-936
- 7 Mahmoudi E, Lu Y, Chang SC. et al. Associations of surgeon and hospital volumes with outcome for free tissue transfer by using the national Taiwan population healthcare data from 2001–2012. Plast Reconstr Surg 2017; 140 (03) 455e-465e
- 8 Nuara MJ, Sauder CL, Alam DS. Prospective analysis of outcomes and complications of 300 consecutive microvascular reconstructions. Arch Facial Plast Surg 2009; 11 (04) 235-239
- 9 Ishimaru M, Ono S, Suzuki S, Matsui H, Fushimi K, Yasunaga H. Risk factors for free flap failure in 2,846 patients with head and neck cancer: a national database study in Japan. J Oral Maxillofac Surg 2016; 74 (06) 1265-1270
- 10 Fentiman IS, Tirelli U, Monfardini S. et al. Cancer in the elderly: why so badly treated?. Lancet 1990; 335 (8696): 1020-1022
- 11 de Rijke JM, Schouten LJ, Schouten HC, Jager JJ, Koppejan AG, van den Brandt PA. Age-specific differences in the diagnostics and treatment of cancer patients aged 50 years and older in the province of Limburg, The Netherlands. Ann Oncol 1996; 7 (07) 677-685
- 12 Tarsitano A, Pizzigallo A, Sgarzani R, Oranges CM, Cipriani R, Marchetti C. Head and neck cancer in elderly patients: is microsurgical free-tissue transfer a safe procedure?. Acta Otorhinolaryngol Ital 2012; 32 (06) 371-375
- 13 Fagin AP, Gelesko S, Wax MK, Petrisor D. Morbidity and functional outcomes with head and neck free flap reconstruction in patients aged 90 years or older. J Oral Maxillofac Surg 2017; 75 (07) 1549-1554
- 14 Weaver TS, Wester JL, Gleysteen JP, Peck JJ, Wax MK. Surgical outcomes in the elderly patient after osteocutaneous free flap transfer. Laryngoscope 2014; 124 (11) 2484-2488
- 15 Sierakowski A, Nawar A, Parker M, Mathur B. Free flap surgery in the elderly: Experience with 110 cases aged ≥70 years. J Plast Reconstr Aesthet Surg 2017; 70 (02) 189-195
- 16 Ferrari S, Copelli C, Bianchi B. et al. Free flaps in elderly patients: outcomes and complications in head and neck reconstruction after oncological resection. J Craniomaxillofac Surg 2013; 41 (02) 167-171
- 17 Wu Y, Zhang B, Huang Z, Ruan Y, Huang Z. Study of surgical treatment for elderly patients with head and neck cancer. Int J Oral Maxillofac Surg 2018; 47 (07) 824-829
- 18 Marttila E, Thorén H, Törnwall J, Viitikko A, Wilkman T. Complications and loss of free flaps after reconstructions for oral cancer. Br J Oral Maxillofac Surg 2018; 56 (09) 835-840
- 19 Chen XF, Chen YM, Gokavarapu S, Shen QC, Ji T. Free flap reconstruction for patients aged 85 years and over with head and neck cancer: clinical considerations for comprehensive care. Br J Oral Maxillofac Surg 2017; 55 (08) 793-797
- 20 Turrà F, La Padula S, Razzano S. et al. Microvascular free-flap transfer for head and neck reconstruction in elderly patients. BMC Surg 2013; 13 (Suppl. 02) S27
- 21 Mitchell CA, Goldman RA, Curry JM. et al. Morbidity and survival in elderly patients undergoing free flap reconstruction: a retrospective cohort study. Otolaryngol Head Neck Surg 2017; 157 (01) 42-47
- 22 Kim H, Kim SD, Shim YJ. et al. Is there any age cutoff to treat elderly patients with head and neck cancer? Comparing with septuagenarians and octogenarians. J Korean Med Sci 2016; 31 (08) 1300-1306
- 23 Reiter M, Baumeister P, Jacobi C. Head and neck reconstruction in the elderly patient: a safe procedure?. Eur Arch Otorhinolaryngol 2017; 274 (08) 3169-3174
- 24 Serletti JM, Higgins JP, Moran S, Orlando GS. Factors affecting outcome in free-tissue transfer in the elderly. Plast Reconstr Surg 2000; 106 (01) 66-70
- 25 Frederick JW, Sweeny L, Carroll WR, Peters GE, Rosenthal EL. Outcomes in head and neck reconstruction by surgical site and donor site. Laryngoscope 2013; 123 (07) 1612-1617
- 26 Goh CS, Kok YO, Yong CP. et al. Outcome predictors in elderly head and neck free flap reconstruction: a retrospective study and systematic review of the current evidence. J Plast Reconstr Aesthet Surg 2018; 71 (05) 719-728
- 27 Wähmann M, Wähmann M, Henn D. et al. Geriatric patients with free flap reconstruction: a comparative clinical analysis of 256 cases. J Reconstr Microsurg 2020; 36 (02) 127-135
- 28 Patel VM, Stern C, Miglani A. et al. Evaluation of the relationship between age and outcome after microvascular reconstruction among patients with recurrent head and neck squamous cell carcinoma. J Reconstr Microsurg 2017; 33 (05) 336-342
- 29 Bhama PK, Patel SA, Khan U, Bhrany AD, Futran ND. Head and neck free flap reconstruction in patients older than 80 years. J Reconstr Microsurg 2014; 30 (08) 523-530
- 30 Spyropoulou GA, Jeng SF, Hsieh CH, Tsimponis A, Shih HS. Microsurgical reconstruction for head and neck cancer in elderly patients. J Reconstr Microsurg 2014; 30 (02) 91-96
- 31 Howard MA, Cordeiro PG, Disa J. et al. Free tissue transfer in the elderly: incidence of perioperative complications following microsurgical reconstruction of 197 septuagenarians and octogenarians. Plast Reconstr Surg 2005; 116 (06) 1659-1668 , discussion 1669–1671
- 32 Arozullah AM, Daley J, Henderson WG, Khuri SF. The National Veterans Administration Surgical Quality Improvement Program. Multifactorial risk index for predicting postoperative respiratory failure in men after major noncardiac surgery. Ann Surg 2000; 232 (02) 242-253
- 33 Loeffelbein DJ, Julinek A, Wolff KD, Kochs E, Haller B, Haseneder R. Perioperative risk factors for postoperative pulmonary complications after major oral and maxillofacial surgery with microvascular reconstruction: a retrospective analysis of 648 cases. J Craniomaxillofac Surg 2016; 44 (08) 952-957
- 34 Lin JAJ, Loh CYY, Tsai CH, Chang KP, Wu JC, Kao HK. Free flap outcomes of microvascular reconstruction after repeated segmental mandibulectomy in head and neck cancer patients. Sci Rep 2019; 9 (01) 7951
- 35 Chaine A, Pitak-Arnnop P, Hivelin M, Dhanuthai K, Bertrand JC, Bertolus C. Postoperative complications of fibular free flaps in mandibular reconstruction: an analysis of 25 consecutive cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108 (04) 488-495
- 36 Kroll SS, Schusterman MA, Reece GP. et al. Choice of flap and incidence of free flap success. Plast Reconstr Surg 1996; 98 (03) 459-463