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DOI: 10.1055/s-0041-1740241
Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation
Funding Information This work was financially supported by the National Science and Technology Major Project (Grant No. 2018ZX09711002-002-009), the National Natural Science Foundation of China (Grant No. 81703358), and Science and Technology Commission of Shanghai Municipality (Grant No. 17431903900, 18QB1404200, and 21S11908000).
Abstract
This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with diastereomeric excess of 94%), which could be used as important raw materials for the preparation of related cannabinoid drugs.
# These authors contributed equally to this work.
Publikationsverlauf
Eingereicht: 29. November 2020
Angenommen: 29. September 2021
Artikel online veröffentlicht:
20. Dezember 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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