Endoscopy 2016; 48(S 01): E311-E312
DOI: 10.1055/s-0042-115941
Cases and Techniques Library (CTL)
© Georg Thieme Verlag KG Stuttgart · New York

Adenomyomatous hyperplasia of the lower bile duct mimicking a papillary bile duct tumor

Yoshikuni Nagashio
1   Department of Hepato-Biliary-Pancreatology, National Kyushu Cancer Center, Fukuoka, Japan
,
Terumasa Hisano
1   Department of Hepato-Biliary-Pancreatology, National Kyushu Cancer Center, Fukuoka, Japan
,
Yoshifusa Aratake
1   Department of Hepato-Biliary-Pancreatology, National Kyushu Cancer Center, Fukuoka, Japan
,
Eiji Tsujita
2   Department of Hepato-Biliary-Pancreatic Surgery, National Kyushu Cancer Center, Fukuoka, Japan
,
Fumiyoshi Fushimi
3   Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan
,
Kenichi Taguchi
3   Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan
,
Masayuki Furukawa
1   Department of Hepato-Biliary-Pancreatology, National Kyushu Cancer Center, Fukuoka, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
26 September 2016 (online)

Adenomyomatous hyperplasia is an extremely rare benign lesion of the hepatobiliary tract, including the ampulla of Vater, with most cases described in the gallbladder [1] [2] [3] [4]. However, its importance lies in its ability to mimic bile duct tumors [1] [2].

A 66-year-old man without jaundice was found to have dilatation of the common and intrahepatic bile ducts on ultrasonography performed during ambulant treatment of diabetes mellitus and hypertension. An enhanced computed tomography (CT) scan showed a mass lesion in the lower bile duct ([Fig. 1]). Endoscopic ultrasonography (EUS) revealed a hypoechoic lesion in the bile duct portion of the ampulla of Vater, with the lesion also extending to the lower bile duct ([Fig. 2 a]), suggesting a papillary bile duct tumor. EUS-guided fine needle aspiration (EUS-FNA) of the bile duct lesion was therefore performed, and microscopic examination showed no apparent malignant cells ([Fig. 2 b]).

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Fig. 1 Abdominal contrast-enhanced computed tomography (CT) scan showing a mass lesion (yellow arrows) in the lower bile duct: a in the axial plane; b in the coronal plane.
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Fig. 2 The lesion in the lower bile duct was shown: a on linear array endoscopic ultrasonography (EUS), to be a 14.9-mm hypoechoic mass (yellow arrows); b on histology from an EUS-guided fine needle aspiration (FNA), to have no apparent malignant cells (hematoxylin and eosin [H&E] stain, original magnification × 200).

Endoscopic retrograde cholangiography (ERCP) showed an irregular stricture in the lower bile duct ([Fig. 3 a]), while intraductal ultrasound and peroral cholangioscopy by SpyGlass demonstrated that this stricture was caused by a papillary mass ([Fig. 3 b, c]; [Video 1]). The endoscopic transpapillary biopsy specimen of this papillary mass showed no apparent malignant cells ([Fig. 4]); however, the possibility of a tumor could not be completely excluded and we therefore performed pancreatoduodenectomy. Histologically, the bile duct epithelium was structurally papillary, and mildly atypical glands and hyperplasia of smooth muscle fibers were observed ([Fig. 5]). The papillary bile duct lesion was finally diagnosed as adenomyomatous hyperplasia.

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Fig. 3 Appearance of the lesion on: a endoscopic retrograde cholangiography showing an irregular stricture at the lower bile duct; b intraductal ultrasound; and c peroral cholangioscopy by SpyGlass showing that the stricture was caused by a papillary mass.


Quality:
Peroral cholangioscopy by SpyGlass showing that the stricture in the lower bile duct was caused by a papillary mass.

Zoom Image
Fig. 4 Histological appearance of the endoscopic transpapillary biopsy taken from the papillary mass showed no apparent malignant cells (hematoxylin and eosin [H&E] stain, original magnification × 200).
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Fig. 5 Histological appearance of the hematoxylin and eosin (H&E)-stained specimen that was resected at pancreatoduodenectomy showed papillary hyperplasia of the surface mucosa and dilated glands surrounded by hyperplastic smooth muscle fibers at original magnifications of: a × 12.5; b × 200.

No specific imaging features permit the reliable differentiation of adenomyomatous hyperplasia from tumor; however, a possible diagnosis of adenomyomatous hyperplasia should be kept in mind in a patient with bile duct stricture. For accurate preoperative diagnosis, it is important to obtain enough biopsy specimens confirming hyperplastic glands surrounded by smooth muscle fibers.

Endoscopy_UCTN_Code_CCL_1AZ_2AC

 
  • References

  • 1 Imai S, Uchiyama S, Suzuki T et al. Adenomyoma of the common hepatic duct. J Gastroenterol 1995; 30: 547-550
  • 2 Numata M, Morinaga S, Watanabe T et al. A case of adenomyomatous hyperplasia of the extrahepatic bile duct. Case Rep Gastroenterol 2011; 5: 457-462
  • 3 Handra-Luca A, Terris B, Couvelard A et al. Adenomyoma and adenomyomatous hyperplasia of the Vaterian system: clinical, pathological, and new immunohistochemical features of 13 cases. Mod Pathol 2003; 16: 530-536
  • 4 Albores-Saaredra J, Henson DE, Klimstra DS. Tumors of the gallbladder, extrahepatic bile ducts, and Vaterian system (AFIP atlas of tumor pathology, series IV), volume 23. Rockville, Maryland: American Registry of Pathology; 2015