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Gallbladder Neuroendocrine Carcinoma: A Case Report with Radiological–Pathological Correlation
Neuroendocrine tumors (NET) of the biliary system, specifically the gallbladder (GB), are extremely rare, accounting for only 0.2% of all NETs. The majority of GBNETs are discovered by chance during a histological examination of GB samples at autopsy, after cholecystectomy, or after surgery for other suspected biliary pathology. GBNETs are thought to develop from preexisting endocrine cells in the GB's neck or from induced endocrine cells caused by intestinal metaplasia of the body and fundus. We present a case of squamous cell carcinoma of the GB with neuroendocrine differentiation due to its rarity.
Ethical clearance was taken from ethical committee. Informed consent was taken from the kin of the deceased.
Article published online:
24 February 2022
© 2022. Indian Society of Gastrointestinal and Abdominal Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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- 1 Baxi AJ, Chintapalli K, Katkar A, Restrepo CS, Betancourt SL, Sunnapwar A. Multimodality imaging findings in carcinoid tumors: a head-to-toe spectrum. Radiographics 2017; 37 (02) 516-536
- 2 Monier A, Saloum N, Szmigielski W, Alrashid A, Napaki SM. Neuroendocrine tumor of the gallbladder. Pol J Radiol 2015; 80: 228-231
- 3 Mezi S, Petrozza V, Schillaci O. et al. Neuroendocrine tumors of the gallbladder: a case report and review of the literature. J Med Case Reports 2011; 5: 334
- 4 Eltawil KM, Gustafsson BI, Kidd M, Modlin IM. Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy. J Clin Gastroenterol 2010; 44 (10) 687-695
- 5 Levy AD, Murakata LA, Rohrmann Jr CA. Gallbladder carcinoma: radiologic-pathologic correlation. [published correction appears in Radiographics 2001 May-Jun;21(3):766]Radiographics 2001; 21 (02) 295-314 , 549–555
- 6 Yadav R, Jain D, Mathur SR, Sharma A, Iyer VK. Gallbladder carcinoma: an attempt of WHO histological classification on fine needle aspiration material. Cytojournal 2013; 10: 12
- 7 Yun SP, Shin N, Seo HI. Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. World J Gastroenterol 2015; 21 (01) 269-275
- 8 Lee SW, Baek SY, Sung SH. Combined undifferentiated and neuroendocrine carcinomas of the gallbladder appearing as two separate lesions: a case report with radiological-pathological correlation. J Radiol Case Rep 2015; 9 (05) 14-21
- 9 Hussain I, Sarvepalli D, Zafar H, Jehanzeb S, Ullah W. Neuroendocrine tumor: a rare, aggressive tumor of the gallbladder. Cureus 2019; 11 (09) e5571
- 10 Maxwell JE, Howe JR. Imaging in neuroendocrine tumors: an update for the clinician. Int J Endocr Oncol 2015; 2 (02) 159-168
- 11 Wang LX, Liu K, Lin GW, Jiang T. Primary hepatic neuroendocrine tumors: comparing CT and MRI features with pathology. Cancer Imaging 2015; 15 (01) 13
- 12 Tan EH, Tan CH. Imaging of gastroenteropancreatic neuroendocrine tumors. World J Clin Oncol 2011; 2 (01) 28-43