CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(01): e97-e103
DOI: 10.1055/s-0042-1742767
Original Research

Vocal Folds Leukoplakia: The Efficacy of Vitamin A in the Initial Treatment

Dayane Silvestre Botini
1   Ophthalmology, Otorhinolaryngology, Head and Neck Surgery Department, Universidade Estadual Paulista(Unesp), Botucatu, SP, Brazil
,
Sergio Augusto Rodrigues 
2   Biostatical Department, Universidade Estadual Paulista (Unesp), Botucatu, SP, Brazil
,
Gustavo Leão Castilho
1   Ophthalmology, Otorhinolaryngology, Head and Neck Surgery Department, Universidade Estadual Paulista(Unesp), Botucatu, SP, Brazil
,
Gustavo Mercuri
1   Ophthalmology, Otorhinolaryngology, Head and Neck Surgery Department, Universidade Estadual Paulista(Unesp), Botucatu, SP, Brazil
,
Regina Helena Garcia Martins 
1   Ophthalmology, Otorhinolaryngology, Head and Neck Surgery Department, Universidade Estadual Paulista(Unesp), Botucatu, SP, Brazil
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Abstract

Introduction Laryngeal leukoplakia corresponds to a white lesion in the mucosa developed by the deposit of keratin in the epithelium, potentiated by chronic smoking. It is considered a preneoplastic lesion. Surgery is the most adopted treatment; however, non-surgical treatment is advocated by some authors.

Objective To evaluate the effectiveness of vitamin A in the management of vocal fold leukoplakia.

Methods Patients with videolaryngoscopy diagnosis of vocal fold leukoplakia were selected. The endoscopic images were photographed and with the aid of the ImageJ software (National Institutes of Health, Bethesda, MD, USA), the proportion of the size of the leukoplakia was calculated. Eligible patients were prescribed 50,000U of vitamin A, twice daily for 2 months, at which point videolaryngostroboscopy was repeated for comparative analysis between pre and posttreatment. The efficacy of the treatment was classified as: outcome I – complete improvement of the lesion, outcome II – partial improvement, and outcome III – no difference or increased lesion size.

Results Fifteen patients (eight women, seven men) were included, six of whom had bilateral lesions. Smoking was reported in 86.8% of patients. Complete improvement of the lesion was found in 7 cases (33.4%, outcome I), partial improvement in 6 (28.6%, outcome II), and worsening of the injury in 8 (38.1%, outcome III). Of the latter, 6 underwent microsurgery; histopathology indicated absence of dysplasia in 3, and mild dysplasia in 3.

Conclusions In this study, the treatment with vitamin A at a dose of 100,000 IU daily for 2 months was effective in reducing the laryngeal leukoplakia size in 62% of cases.

Keywords

leukoplakia - vocal folds - larynx - vitamin A - treatment


Publication History

Received: 26 May 2021

Accepted: 14 December 2021

Article published online:
10 November 2022

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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