Oncocytic Meningioma: Case Report of a Rare Meningioma Variant

Abstract

Oncocytic meningioma has been first identified in 1997 as a rare meningioma variant, composed predominantly of large meningothelial cells with abundant intracytoplasmic mitochondria. Here, we describe a 34-year-old male patient presenting with 2 weeks of progressive holocranial headache. Brain magnetic resonance imaging (MRI) revealed an extra axial solid-cystic expansive lesion in the left parieto-occipital parasagittal region, with intense vascularization. Histological and immunohistochemical analysis established the diagnosis. We also review briefly the pathological and radiological findings of this rare variant of meningioma as described in the literature.

Resumo

O meningioma oncocítico foi identificado pela primeira vez em 1997 como uma variante rara do meningioma, composta predominantemente por grandes células meningoteliais com abundantes mitocôndrias intracitoplasmáticas. Aqui, descrevemos um paciente do sexo masculino de 34 anos apresentando cefaleia holocraniana progressiva de 2 semanas. A ressonância magnética (RM) do cérebro revelou lesão expansiva sólido-cística extra-axial em região parassagital parieto-occipital esquerda, com intensa vascularização. A análise histológica e imuno-histoquímica estabeleceu o diagnóstico. Também revisamos brevemente os achados patológicos e radiológicos desta variante rara de meningioma, conforme descrito na literatura.

Keywords

meningioma - mitochondria - pathology

Palavras-chave

meningioma - mitocôndrias - patologia

Publikationsverlauf

Eingereicht: 17. Juli 2021

Angenommen: 13. Oktober 2021

Artikel online veröffentlicht:
05. September 2022

• References

• 1 Marucci G, Betts CM, Frank G, Foschini MP. Oncocytic meningioma: report of a case with progression after radiosurgery. Int J Surg Pathol 2007; 15 (01) 77-81
• 2 Louis D, Ohgaki H, Wiestler O. et al. WHO Classification of Tumours of the Central Nervous System (Revised 4th edition). IARC; Lyon: 2016
• 3 Caldarella A, Buccoliero AM, Marini M, Taddei A, Mennonna P, Taddei GL. Oncocytic meningioma: a case report. Pathol Res Pract 2002; 198 (02) 109-113
• 4 Giangaspero F, Cenacchi G. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Semin Diagn Pathol 1999; 16 (02) 91-97
• 5 Zunarelli E, Tallarico E, Valentini A, Maiorana A. Oncocytic meningioma: study of eight new cases and analysis of 13 reported cases. Pathology 2010; 42 (06) 587-589
• 6 Sasagawa Y, Tachibana O, Iida T, Iizuka H. Oncocytic meningioma presenting with intratumoral hemorrhage. J Clin Neurosci 2013; 20 (11) 1622-1624
• 7 Roncaroli F, Riccioni L, Cerati M. et al. Oncocytic meningioma. Am J Surg Pathol 1997; 21 (04) 375-382
• 8 Niiro M, Ishimaru K, Hirano H, Yunoue S, Kuratsu J. Clinico-pathological study of meningiomas with haemorrhagic onset. Acta Neurochir (Wien) 2003; 145 (09) 767-772
• 9 Zheng J, Geng M, Shi Y, Jiang B, Tai Y, Jing H. Oncocytic meningioma: a case report and review of the literature. Surg Oncol 2013; 22 (04) 256-260
• 10 Nagai Yamaki V, de Souza Godoy LF, Alencar Bandeira G. et al. Dural-based lesions: is it a meningioma?. Neuroradiology 2021; 63 (08) 1215-1225
• 11 Lyndon D, Lansley JA, Evanson J, Krishnan AS. Dural masses: meningiomas and their mimics. Insights Imaging 2019; 10 (01) 11
• 12 Cannon J. The significance of hurthle cells in thyroid disease. Oncologist 2011; 16 (10) 1380-1387
• 13 Máximo V, Sobrinho-Simões M. Mitochondrial DNA ‘common’ deletion in Hürthle cell lesions of the thyroid. J Pathol 2000; 192 (04) 561-562
• 14 Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M. The biology and the genetics of Hurthle cell tumors of the thyroid. Endocr Relat Cancer 2012; 19 (04) R131-R147
• 15 Rogers L, Barani I, Chamberlain M. et al. Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 2015; 122 (01) 4-23