Endoscopy 2022; 54(S 01): S11-S12
DOI: 10.1055/s-0042-1744577
Abstracts | ESGE Days 2022
ESGE Days 2022 Oral presentations
09:30–10:30 Thursday, 28 April 2022 Club H. Diagnostic and therapeutic EUS in pancreatic disease

REPEATED EUS-GUIDED FINE NEEDLE BIOPSY AFTER NON-DIAGNOSTIC OR INCONCLUSIVE RESULTS OF SOLID PANCREATIC MASSES – THE REUBIO STUDY

A. Cominardi
1   University of Bologna, Gastroenterology Unit, Hospital of Imola, Imola, Italy
,
A. Lisotti
1   University of Bologna, Gastroenterology Unit, Hospital of Imola, Imola, Italy
,
S.F. Crinò
2   University of Verona, Verona, Italy
,
A. Larghi
3   Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
,
A. Facciorusso
4   University of Foggia, Foggia, Italy
,
C. Fabbri
5   Forlì-Cesena Hospitals, AUSL Romagna, Forlì, Italy
,
H. Bertani
6   University of Modena, Modena, Italy
,
C. De Angelis
7   Città della Salute e della Scienza di Torino, Torino, Italy
,
F.M. Di Matteo
8   Campus Biomedico, Roma, Italy
,
A. Pisani
9   National Institute of Research “Saverio De Bellis”, Castellana Grotte, Italy
,
M.L. Brancaccio
10   Ravenna Hospital, AUSL Romagna, Ravenna, Italy
,
E. Dabizzi
11   Maggiore Hospital of Bologna, Bologna, Italy
,
A. Grillo
12   Hospital of Rimini, AUSL Romagna, Rimini, Italy
,
A. Fantin
13   Veneto Institute of Oncology IOV-IRCCS, Padova, Italy
,
A. Pezzoli
14   Hospital of Ferrara, Ferrara, Italy
,
F. Decembrino
15   Miulli Hospital, Acquaviva delle Fonti, Italy
,
A. Amato
16   Valduce Hospital, Como, Italy
,
T. Togliani
17   Hospital of Mantova, Mantova, Italy
,
F. Antonini
18   Hospital of Fermo, Fermo, Italy
,
A. Montale
19   Galliera Hospital of Genova, Genova, Italy
,
E. Forti
20   Niguarda Hospital, Milano, Italy
,
V. Cennamo
11   Maggiore Hospital of Bologna, Bologna, Italy
,
M. Manno
21   Hospital of Carpi, AUSL Modena, Carpi, Italy
,
S. Carrara
22   Humanitas Research Hospital, Milano, Italy
,
P.G. Arcidiacono
23   San Raffaele Hospital, Milano, Italy
,
B. Mangiavillano
24   Humanital Mater Domini, Castellanza, Italy
,
C. Binda
5   Forlì-Cesena Hospitals, AUSL Romagna, Forlì, Italy
,
G. Aragona
25   Hospital of Piacenza, Piacenza, Italy
,
A. Mussetto
10   Ravenna Hospital, AUSL Romagna, Ravenna, Italy
,
M.C. Conti Bellocchi
2   University of Verona, Verona, Italy
,
S. Stigliano
8   Campus Biomedico, Roma, Italy
,
E. Gasparini
2   University of Verona, Verona, Italy
,
G. Rizzatti
3   Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
,
M.G. Pellegrino
3   Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy
,
N. Muscatiello
4   University of Foggia, Foggia, Italy
,
G. Marocchi
5   Forlì-Cesena Hospitals, AUSL Romagna, Forlì, Italy
,
S. Mangiafico
6   University of Modena, Modena, Italy
,
M. Lupo
6   University of Modena, Modena, Italy
,
O. Burattini
9   National Institute of Research “Saverio De Bellis”, Castellana Grotte, Italy
,
R. Lovero
9   National Institute of Research “Saverio De Bellis”, Castellana Grotte, Italy
,
S. Fabbri
10   Ravenna Hospital, AUSL Romagna, Ravenna, Italy
,
E. Dall'Amico
7   Città della Salute e della Scienza di Torino, Torino, Italy
,
F. D'Errico
15   Miulli Hospital, Acquaviva delle Fonti, Italy
,
T. Gabbani
21   Hospital of Carpi, AUSL Modena, Carpi, Italy
,
R.M. Zagari
26   University of Bologna, Bologna, Italy
,
P. Fusaroli
1   University of Bologna, Gastroenterology Unit, Hospital of Imola, Imola, Italy
› Author Affiliations
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Aims To evaluate the diagnostic yield of repeated EUS-FNB(rEUS-FNB) of pancreatic masses after previous non-diagnostic or inconclusive EUS-tissue acquisition(EUS-TA).

Methods A retrospective study retrieving consecutive patients who underwent rEUS-FNB for pancreatic masses at 26 Italian hospitals from July 2017 to July 2021 was conducted. Results are expressed in terms of odd ratio and 95%confidence intervals.

Results Three-hundred-42 patients were included(55.6% male, median age 69.5[60-76]); in 277(81%) cases a 2nd-generation EUS-FNB needle (fork-tip, Franseen-type or forward-bevel) was used, median 3[2-3] passes. ROSE was available in 63(18.4%) cases. Final diagnosis revealed malignancy in 255(74.6%) cases.

Repeated-EUS-FNB adequacy, sensitivity, specificity and accuracy were 91.1%, 91.2%, 91.1% and 90.5%, respectively. Positive and negative predictive values were 97.5% and 72.9%.

On univariate analysis, rEUS-FNB performed in high-volume centers (OR 2.79 [1.10-7.10])was related to sample adequacy while ROSE was not. On multivariate, the use of 2nd-generation EUS-FNB needles was the only variable independently related to sample adequacy (OR 4.40, 95% CI 0.10-1.40).

On univariate analysis, previous EUS-FNB was inversely related to accuracy (OR 0.38 [0.15-0.91]), while use of 2nd-generation EUS-FNB needles (OR 2.54 [1.25-5.18] was directly correlated; on multivariate analysis, the use of fork-tip needle (OR 11.57 [1.54-87.10]) and number of needle passes<3 (OR 0.50 [0.25-0.99]) were independently related to rEUS-FNB accuracy.

Conclusions Repeated-EUS-FNB showed optimal adequacy and accuracy after previous non-diagnostic or inconclusive EUS-TA of pancreatic masses.

Our data suggested that use of 2nd-generation EUS-FNB needles,>2 needle passes and patients referral to high-volume center may further increase sample adequacy and diagnostic accuracy.



Publication History

Article published online:
14 April 2022

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