EVALUATION OF THE EFFECT OF GASTRIC TARGETED BIOPSY SAMPLING WITH I-SCAN OE TECHNOLOGY ON THE DIAGNOSTIC YIELD OF THE CLO TEST OF H. PYLORI INFECTION

Aims to determine if the diagnostic yield of the CLO test could be improved by using endoscopic I-scan OE technology for targeted gastric biopsy sampling

Methods A prospective study recruited 112 Adult patients with active H.pylori infection diagnosed by UBT and/or histology. The patients underwent a careful examination by non-magnifying upper endoscopy and i-scan OE 3 moods, then randomly allocated into group A: non-targeted random double biopsies from the antrum and mid corpus, group B: I-scan OE directed targeted biopsy from abnormal mucosal patterns, the biopsy specimens were inoculated into CLO test kits, The reading time of the positive results was at 1, 4 and 24 hours.

Results Group B had a 92.8% positive CLO test compared to 89.3 in group A (p>0.0.5). One-hour CLO test was positive in 78.5% of the patients in group B compared to 60.7% in group A (p<0.05), while group A had a significantly more positive CLO test at 24 hours.

Conclusions: sampling a targeted gastric biopsy with the aid of I-scan -OE for CLO test hastens significantly the reading time with a high total test sensitivity​​​​

Publication History

Article published online:
14 April 2022