Endoscopy 2022; 54(S 01): S150-S151
DOI: 10.1055/s-0042-1744968
Abstracts | ESGE Days 2022
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OUTCOMES AND RISK FACTORS ASSOCIATED WITH GASTROINTESTINAL BLEEDING AMONG PATIENTS WITH SEVERE COVID-19

G.H.P. de Oliveira
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
D.T.H. de Moura
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
T.R McCarty
2   Brigham and Women’s Hospital – Harvard Medical School, Gastroenterology, Hepatology and Endoscopy, Boston, United States
,
I.M. Proença
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
R.S.d.P. Rocha
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
A.S.T. Kum
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
C.F Moll
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
G.d.O. Luz
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
S. Cheng
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
M.E.L. dos Santos
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
,
E.G.H. de Moura
1   Hospital das Clínicas, University of São Paulo School of Medicine, Gastroenterology, São Paulo, Brazil
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Aims The coronavirus disease 2019 (COVID-19) caused by the novel coronavirus (SARS-CoV-2), most commonly associated with being a respiratory illness may manifest with multi-organ involvement, including the gastrointestinal (GI) system. Given the ongoing pandemic, there is an urgent need to understand the impact of GIB among a population of patients with COVID-19. Therefore, we sought to evaluate patients with severe COVID-19 and assess outcomes and risk factors associated with GIB.

Methods This was a single-center cohort study of a quaternary hospital in São Paulo, Brazil. Following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement, we retrospectively analyzed a cohort of hospitalized patients with severe COVID-19 who were admitted to the ICU from March 2020 to May 2021. Comparison of demographis, symptoms, laboratory data, and clinical outcomes were compared between GIB vs non-GIB groups. Multivariable regression analyses were performed to evaluate risk factors related to GIB and critical care outcomes, including in-hospital mortality.

Results A total of 285 critically ill patients with COVID-19 were evaluated [29.82% with GIB vs 70.18% without GIB]. Patients with GIB were found to have increased in-hospital mortality (65.88% vs 37.00%;p=0.0001) and length of hospitalization (37.44±30.02 vs 19.88±11.60 days;p<0.0001). On multivariable regression, obesity was a significant risk factor for GIB [OR 66.09 (95% CI 3.80-1151.00); p=0.004)] ([Table 1]).

Table 1

Logistic Regression for Gastrointestinal Bleeding

Odds Ratio

95% Confidence Interval

P Value

Male Gender

1,13

0.47 to 2.70

0.780

Obesity

66,09

3.80 to 1151.00

0.004

Chronic Kidney Disease

0,47

0.16 to 1.39

0.174

Gastrointestinal Symptoms

1,49

0.56 to 3.96

0.425

Conclusions In conclusion, patients with severe COVID-19 and GIB had a significantly longer duration of hospitalization and increased mortality compared to patients without GIB. Notably, obesity was found to vastly increase the risk of GIB.



Publication History

Article published online:
14 April 2022

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