Endoscopy 2022; 54(S 01): S182-S183
DOI: 10.1055/s-0042-1745058
Abstracts | ESGE Days 2022
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GASTROINTESTINAL BLEEDING AND ENDOSCOPIC FINDINGS IN CRITICALLY AND NON-CRITICALLY ILL PATIENTS WITH COVID-19: RESULTS FROM LEOSS AND COKA REGISTRIES

S. Zellmer
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
F. Hanses
2   University Hospital Regensburg, Emergency Department, Regensburg, Germany
3   University Hospital Regensburg, Department of Infection Prevention and Infectious Diseases, Regensburg, Germany
,
A. Muzalyova
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
J. Classen
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
G. Braun
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
C. Piepel
4   Klinikum Bremen-Mitte, Department of Hematooncology and Infectiology, Bremen, Germany
,
J. Erber
5   Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Department of Internal Medicine II, Munich, Germany
,
L. Pilgram
6   Goethe University Frankfurt, Department of Internal Medicine, Hematology and Oncology, Frankfurt, Germany
,
L. Walter
7   Hospital St. Joseph-Stift Dresden, Clinic for Anesthesiology, Dresden, Germany
,
S. Göpel
8   University of Bochum, University Clinic for Haematology, Oncology, Haemostaseology and Palliative Care, Johannes Wesling Klinikum, Minden, Germany
,
M. Hower
9   Klinikum Dortmund, Department of Pneumology, Infectious Diseases and Internal Medicine, Dortmund, Germany
,
M.M. Rüthrich
10   University Hospital Jena, Department of Internal Medicine II, Hematology and Medical Oncology, Jena, Germany
,
M. Stecher
11   University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany
12   German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany
,
C. Jakob
11   University Hospital of Cologne, Department I of Internal Medicine, Cologne, Germany
12   German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany
,
C. Dhillon
13   COVID-19 Task Force, University Hospital Augsburg, Augsburg, Germany
,
H. Messmann
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
A. Ebigbo
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
,
C. Römmele
1   University Hopsital Augsburg, Clinic for Internal Medicine III – Gastroenterology and Infectious Diseases, Augsburg, Germany
13   COVID-19 Task Force, University Hospital Augsburg, Augsburg, Germany
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Aims COVID-19 patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased.

Methods We considered 4128 COVID-19 patients enrolled in the LEOSS registry. Association between occurrence of GI bleeding and comorbidities as well as medication were examined. Additionally, 1216 patients from the COKA registry were analyzed focusing on endoscopic findings.

Results A total of 97 patients (1.8%) with GI bleeding were identified in the LEOSS and COKA registries. Of 4128 patients from the LEOSS registry, 66 patients (1.6%) had a GI bleeding. In ICU patients the rate was 4.5%. Use of therapeutic dose of anticoagulants showed a significant association with increased incidence of bleeding in the critical phase of disease. The Charlson comorbidity index and the COVID-19 severity index were significantly higher in patients with GI bleeding than in patients without GI bleeding (5.83(SD=2.93) vs. 3.66(SD=3.06), p<0.01 and 3.26(SD=1.69) vs. 2.33(SD=1.53), p<0.01, respectively). In the COKA registry 31 patients (2.5%) developed a GI bleeding. Of these, the source of bleeding was identified in upper GI tract in 21 patients (67.7%) with ulcer as the most frequent bleeding source (25.8%, n=8) followed by gastroesophageal reflux (16.1%, n=5). In 3 patients (9.7%) GI bleeding source was located in lower GI tract caused mainly by diverticular bleeding (6.5%, n=2). In 7 patients (22.6%) the bleeding localization remained unknown.

Conclusions Risk of GI bleeding seems not to be increased in COVID-19 patients. Consistent with previous findings, comorbidities and disease severity correlate with the incidence of GI bleeding.



Publication History

Article published online:
14 April 2022

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