CC BY-NC-ND 4.0 · Laryngorhinootologie 2022; 101(S 02): S222
DOI: 10.1055/s-0042-1746615
Poster
Head-Neck-Oncology: Tumor surgery / Functional Reconstructive Surgery

Evaluation of the influence of lymphnode burden/nodal yield and lymphnode density as prognostic markers of neck dissections on the outcome in patients with total laryngectomy

Jördis Kristin Eden
1   UKE Hamburg, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Kopf- und Neurozentrum Hamburg
,
Stefan Bartels
2   UKE Hamburg, Universitäres Cancer Center Hamburg (UCCH) Hamburg
,
Arne Böttcher
1   UKE Hamburg, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Kopf- und Neurozentrum Hamburg
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Background Controversies exist in regard to surgical neck management in total laryngectomies (TL). International guidelines do not sufficiently discriminate neck sides and sublevels, or minimal neck-dissection nodal yield (NY). The lymph node burden (LNB) ist the number of metastatic lymph nodes, the lymph node density (LND) is the number of positive metastatic lymph nodes divided by the total number of dissected lymph nodes. The purpose of this study was to evaluate NY, LNB and LND as prognostic factors in patients with laryngeal squamous cell carcinoma.

Methods We analyzed a cohort of fourty-six consecutive primary total laryngectomy cases from 2009 to 2021 retrospectively in terms of local neck involvement to determine the prognostic value of nodal yield, lymph node burden and lymph node density on survival.

Results The median NY was 65,5 (SD 29,2 Range 4-149). The median LNB was 0,0 (SD 1,67 Range 0-7). The median LND was 0,0 (SD 0,11 Range 0-0,75). We could demonstrate a significant influence of lymph node burden and lymph node density on the overall- and desease-free-survival.

Conclusions This work sheds light on regional metastatic distribution pattern and its influence on total laryngectomy cases. Here, we present cut-off values that might be suitable prognosticators for TL cases.



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Artikel online veröffentlicht:
24. Mai 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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