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DOI: 10.1055/s-0042-1751569
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Japan/Netherlands Gratama Workshop

Bioorthogonal Chemistry at Radboud University: Past, Present and Future

Floris P. J. T. Rutjes  ∗
,
Kimberly M. Bonger  ∗
,
Kevin Neumann  ∗
We are grateful for continuing financial support including from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), the European Research Council (ERC), and the Dutch Society for Immunology (NVVI). K.B. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 802940) and the NWO gravitation program ‘Institute for Chemical Immunology’ (NWO-024.002.009).
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Abstract

Over the past two decades, bioorthogonal chemistry has profoundly impacted various chemistry-related fields, including chemical biology and drug delivery. This transformative progress stems from collaborative efforts involving chemists and biologists, underscoring the importance of interdisciplinary research. In this Account, we present the developments in bioorthogonal chemistry within our Institute for Molecules and Materials at Radboud University. The chemistry disclosed here spans from strained alkynes and alkenes to drug release and bioconjugation strategies, mirroring the extensive scope provided by bioorthogonal chemistry. By reflecting on the chemistry originating at Radboud University, this Account emphasizes that teamwork is essential for driving significant progress in bioorthogonal chemistry.

1 Introduction

2 Providing BCN as a Robust Bioorthogonal Tool for Chemical Biology and Beyond

3 Towards Readily Available Click-to-Release trans-Cyclooctenes

4 Giving Molecules Guidance

5 Next Generation of Bioconjugation Strategies: Dynamic Click Chemistry

6 Conclusions

Keywords

bioorthogonal chemistry - chemical biology - strained alkynes - tetrazines - drug activation


Publication History

Received: 21 January 2024

Accepted after revision: 14 February 2024

Article published online:
14 March 2024

© 2024. The Authors. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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