Primary Intracranial Choriocarcinoma in the Suprasellar Region: A Case Report

Abstract

A 17-year-old boy was admitted to our hospital with history of headache, nausea, and visual field disturbances for about a year. A suprasellar tumor was found by computed tomography and magnetic resonance imaging. Biopsy of this lesion showed primary intracranial choriocarcinoma on histopathological examination. The human chorionic gonadotropin (hCG) level was measured in serum and cerebrospinal fluid after the biopsy, and was elevated in both. The patient went into chemotherapy and surgery with no complications or recurrence. If young patients present with a suprasellar lobulated mass with hemorrhage, the serum hCG level should be measured before surgery.

Keywords

magnetic resonance imaging - primary intracranial choriocarcinoma - serum hCG - suprasellar tumor

Publikationsverlauf

Eingereicht: 14. Mai 2022

Angenommen: 05. Juli 2022

Artikel online veröffentlicht:
15. September 2022

• References

• 1 Li X, Murayama K, Watanabe A, Abe M, Toyama H. Primary intracranial choriocarcinoma located in the suprasellar region. Open Neuroimaging J 2016; 10: 80-84
• 2 Cheung AN, Zhang HJ, Xue WC, Siu MK. Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives. Future Oncol 2009; 5 (02) 217-231
• 3 Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma. J Neurol Neurosurg Psychiatry 1986; 49 (01) 93-95
• 4 Yamagami T, Handa H, Takeuchi J, Niijima K, Furukawa F. Choriocarcinoma arising from the pituitary fossa with extracranial metastasis: a review of the literature. Surg Neurol 1983; 19 (05) 469-480
• 5 Kageji T, Nagahiro S, Matsuzaki K. et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report. J Neurooncol 2007; 83 (02) 199-204
• 6 Koyama S, Tsubokawa T, Katayama Y, Hirota H. Choriocarcinoma of the septum pellucidum: case report. Surg Neurol 1991; 35 (06) 478-482
• 7 Gao Y, Jiang J, Liu Q. Extragonadal malignant germ cell tumors: a clinicopathological and immunohistochemical analysis of 48 cases at a single Chinese institution. Int J Clin Exp Pathol 2015; 8 (05) 5650-5657
• 8 Matsutani M, Sano K, Takakura K. et al. Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg 1997; 86 (03) 446-455
• 9 Kyritsis AP. Management of primary intracranial germ cell tumors. J Neurooncol 2010; 96 (02) 143-149
• 10 Huang CY, Chen CA, Hsieh CY, Cheng WF. Intracerebral hemorrhage as initial presentation of gestational choriocarcinoma: a case report and literature review. Int J Gynecol Cancer 2007; 17 (05) 1166-1171
• 11 Lv X-F, Qiu Y-W, Zhang X-L. et al. Primary intracranial choriocarcinoma: MR imaging findings. AJNR Am J Neuroradiol 2010; 31 (10) 1994-1998
• 12 Liang L, Korogi Y, Sugahara T. et al. MRI of intracranial germ-cell tumours. Neuroradiology 2002; 44 (05) 382-388
• 13 Vaquero J, Martínez R, Manrique M. Stereotactic biopsy for brain tumors: is it always necessary?. Surg Neurol 2000; 53 (05) 432-437 , discussion 437–438
• 14 Fleseriu M, Hashim IA, Karavitaki N. et al. Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2016; 101 (11) 3888-3921
• 15 Prete A, Corsello SM, Salvatori R. Current best practice in the management of patients after pituitary surgery. Ther Adv Endocrinol Metab 2017; 8 (03) 33-48