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Aldosterone-Secreting Large Oncocytic Neoplasm of the Adrenal Gland with Borderline PotentialFunding None.
Adrenal oncocytomas are rare tumors that are mostly benign and non-functional although they may be hormonally active and can exhibit a borderline or malignant potential. We present a case of a 40-year-old female patient with known hypertension who presented with abdominal discomfort. Radiologic investigations showed a large mass on the left adrenal gland. In the hormonal study, an aldosterone-secreting tumor was identified. After laparoscopic resection, the histological assessment of the 12-cm mass showed an oncocytic neoplasm with borderline characteristics. The laboratory results returned to normal and the hypertensive disease improved. The patient was doing well after 14 months of follow-up. This is the seventh documented case of aldosterone-secreting oncocytoma, the first borderline tumor of this type, and the largest reported tumor so far.
Written informed consent was obtained from the patient and is available on request.
K.D. operated on the patient and wrote the first draft. M.A. was involved in the diagnostic work-up and follow-up, collected the clinical data, and edited the manuscript. M.J. examined the specimen and contributed to the pathologic details of the work. M.F.S. researched the documented cases, organized the figures and tables, and edited the discussion. All authors reviewed and approved the final manuscript before submission.
Article published online:
15 September 2022
© 2022. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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