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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2023; 58(03): 495-499
DOI: 10.1055/s-0042-1757963
Artigo Original
Osteometabólica

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis

Article in several languages: português | English
Abel Oliveira Marques Teixeira 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Virmondes Rodrigues-Junior 
2   Disciplina de Imunologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil
,
Bárbara Rocha Rodrigues 
2   Disciplina de Imunologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil
,
Danila Malheiros Souza 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Leonardo Franco Pinheiro Gaia 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Denise Bertulucci Rocha Rodrigues 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
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Abstract

Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients.

Methods The present study was conducted with a blood sample of 62 patients, divided into patients with osteoporosis and healthy patients. The results were obtained using the ELISA method. Cytokine concentrations were determined based on the absorbance values obtained.

Results Serum TNF-alpha levels were undetectable in female patients, while in males they were found only in one patient, with no significant difference. Similar results were found in the analyses of TNF-R1 and TNF-R2 levels, a significant increase in levels of TNF-alpha receptors in the groups of patients with osteoporosis compared with the control group in both sexes. There was no significant difference between the sexes in the dosage of both receptors within the group with osteoporosis. There was also a positive and significant correlation in the levels of TNF-R1 and TNF-R2 only in women.

Conclusion The significant increase in TNF-R1 and TNF-R2 levels in women with osteoporosis suggest that the release and expression of these receptors may be contributing differently to the development of osteoporosis in men and women.

Keywords

osteoporosis - tumor necrosis factor-alpha - receptors, tumor necrosis factor

Work developed in the Department of Orthopedics and Traumatology, Universidade de Uberaba, Uberaba, MG, Brazil




Publication History

Received: 28 November 2021

Accepted: 12 September 2022

Article published online:
29 June 2023

© 2023. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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