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CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2023; 58(03): 495-499
DOI: 10.1055/s-0042-1757963
Artigo Original
Osteometabólica

Análise comparativa de TNF-alfa, TNF-R1 e TNF-R2 em pacientes com fraturas de baixo impacto decorrentes de osteoporose

Article in several languages: português | English
Abel Oliveira Marques Teixeira 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Virmondes Rodrigues-Junior 
2   Disciplina de Imunologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil
,
Bárbara Rocha Rodrigues 
2   Disciplina de Imunologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil
,
Danila Malheiros Souza 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Leonardo Franco Pinheiro Gaia 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
,
Denise Bertulucci Rocha Rodrigues 
1   Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil
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Resumo

Objetivo Analisar os níveis séricos de TNF-alfa e de seus receptores TNF-R1 e TNF-R2 no sangue de pacientes com fraturas de baixo impacto, decorrentes de osteoporose, comparando entre os sexos e com pacientes saudáveis.

Métodos O estudo foi realizado com amostra de sangue de 62 pacientes, divididos em pacientes com osteoporose e pacientes saudáveis. Os resultados foram obtidos através do método de ELISA. As concentrações de citocinas foram determinadas com base nos valores de absorbância obtidos.

Resultados Os níveis séricos de TNF-alfa foram indetectáveis nos pacientes do sexo feminino, enquanto no masculino encontrou-se somente em um paciente, não havendo diferença significativa. Encontrou-se resultados semelhantes nas análises dos níveis de TNF-R1 e TNF-R2, aumento significativo nos níveis dos receptores de TNF-alfa nos grupos de pacientes com osteoporose em comparação com o grupo controle, em ambos os sexos. Não houve diferença significativa entre os sexos na dosagem de ambos os receptores dentro do grupo com osteoporose. Houve ainda correlação positiva e significativa nos níveis de TNF-R1 e TNF-R2 apenas nas mulheres.

Conclusão O aumento significativo nos níveis de TNF-R1 e TNF-R2 em mulheres com osteoporose sugerem que a liberação e expressão destes receptores pode estar contribuindo de maneira distinta no desenvolvimento da osteoporose em homens e mulheres.

Palavras-chave

osteoporose - fator de necrose tumoral alfa - receptores do fator de necrose tumoral

Trabalho realizado no Departamento de Ortopedia e Traumatologia, Universidade de Uberaba, Uberaba, MG, Brasil.




Publication History

Received: 28 November 2021

Accepted: 12 September 2022

Article published online:
29 June 2023

© 2023. Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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