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Drug Res (Stuttg) 2017; 67(06): 358-365
DOI: 10.1055/s-0043-101824
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Mitochondria as a Target for the Cardioprotective Effects of Cydonia oblonga Mill. and Ficus carica L. in Doxorubicin-Induced Cardiotoxicity

Saman Gholami
1   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Mir-Jamal Hosseini
2   Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
,
Leila Jafari
3   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Fatemeh Omidvar
4   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Mohammad Kamalinejad
5   Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Vida Mashayekhi
6   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Seyed Hojjat Hosseini
7   Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
,
Azin Kardan
8   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Jalal Pourahmad
9   Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Mohammad Reza Eskandari
10   Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
› Author Affiliations
Further Information

Publication History

received 07 November 2016

accepted 18 January 2017

Publication Date:
20 March 2017 (online)

Also available at
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Abstract

Background

Quince (Cydonia oblonga Mill.) and fig (Ficus carica L.) exhibit a broad spectrum of pharmacological activities. Regarding the cardiotoxic effect of doxorubicin (DOX) is mediated mainly through mitochondrial oxidative stress and dysfunction; the present study evaluated the cardioprotective effects of the aqueous extracts of Cydonia oblonga Mill. fruit (ACO) and Ficus carica L. fruit (AFC) against DOX-induced cardiotoxicity.

Methods

Cardiomyocytes toxicity was induced in male Sprague Dawley rats by intraperitoneal (ip) injections of 2.5 mg/kg DOX 3 times per week for a period of 2 weeks. After heart failure was induced in the rats, the animals were decapitated and their hearts were immediately removed. Then, the cardiac mitochondria were isolated by differential ultracentrifugation, and the protective effects of each particular extract on mitochondrial oxidative stress and dysfunction were determined.

Results

ACO and AFC ameliorated mitochondrial dysfunction in the isolated mitochondria and prevented mitochondrial reactive oxygen species formation, membrane lipid peroxidation, mitochondrial swelling, mitochondrial membrane potential collapse (%ΔΨm), and cytochrome c release. Also, the extracts significantly increased reduced glutathione levels and succinate dehydrogenase activity.

Conclusion

These results indicated that ACO and AFC have beneficial effects against DOX cardiotoxicity which mediated by attenuating mitochondrial dysfunction. Therefore, it can be suggested that quince and fig may increase the therapeutic index of DOX.

Key words

C. oblonga Mill. - F. carica L. - quince - fig - heart failure - cardiotonic
 

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