Drug Res (Stuttg) 2017; 67(06): 337-342
DOI: 10.1055/s-0043-103575
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Traditional Treatment of Diabetes Mellitus with Xanthosoma sagittifolium on the Male Reproductive System of Alloxan-Induced Diabetic Wistar Rats

Olayinka A. Oridupa
1   Department of Veterinary Physiology, Biochemistry & Pharmacology, University of Ibadan, Ibadan, Nigeria
Oluyemisi F. Folasire
2   Department of Human Nutrition, University of Ibadan, Ibadan, Nigeria
Adedotun J. Owolabi
2   Department of Human Nutrition, University of Ibadan, Ibadan, Nigeria
Oluwasanmi Aina
3   Department of Veterinary Anatomy, University of Ibadan, Nigeria
› Author Affiliations
Further Information

Publication History

received 09 November 2016

accepted 10 February 2017

Publication Date:
13 March 2017 (online)



The management of diabetes mellitus (DM) targets glycemic control as well as prevention or reversal of other complications associated with the metabolic disorder. One of such complications is the infertility which has been traced to oxidative stress and DNA damage caused by DM.

Subjects and methods

In this study, experimentally-induced diabetic male Wistar rats were fed with Xanthosoma sagittifolium (cocoyam) for 14 days and its effect on sperm morphology and characteristics, as well as histology of the testes were assessed. X. sagittifolium corm feed (Xs) were reconstituted with commercial rat feed to contain 25, 50, 75 or 100% X. sagittifolium on a weight/weight basis.


One primary and 7 secondary cell abnormalities were observed with overall increased total abnormal sperm cells in the diabetic rats. Sperm cell motility was significantly (p<0.05) reduced in all diabetic rats, but diabetic rats fed with Xs showed increased motility and liveability. Sperm volume was unchanged, but the depressed sperm count in the untreated diabetic rats was increased in Xs-fed rats. Histology of Xs-fed diabetic rats showed reduction in seminiferous tubule diameter and luminal diameter which was significantly enlarged in untreated diabetic rats.


X. sagittifolium significantly (p<0.05) prevented further deterioration of sperm cell quality and reversed cell apoptosis as presented by increased sperm motility, liveability and count. In the overall, the chances of fertilization by sperm cells from diabetic patients will be increased as well as achievement of good glycemic control and prevention of further damage by the disease condition.