Endoscopy 2017; 49(06): 560-563
DOI: 10.1055/s-0043-106556
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Yoshihiro Nakazato*
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan
,
Makoto Naganuma*
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Shinya Sugimoto
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Rieko Bessho
Center for Preventive Medicine, Keio University School of Medicine, Tokyo, Japan
,
Mari Arai
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Hiroki Kiyohara
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Keiko Ono
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Kosaku Nanki
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Makoto Mutaguchi
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Shinta Mizuno
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Taku Kobayashi
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
,
Naoki Hosoe
Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan
,
Masayuki Shimoda
Department of Pathology, Keio University School of Medicine, Tokyo, Japan
,
Takayuki Abe
Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan
,
Nagamu Inoue
Center for Preventive Medicine, Keio University School of Medicine, Tokyo, Japan
,
Haruhiko Ogata
Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan
,
Yasushi Iwao
Center for Preventive Medicine, Keio University School of Medicine, Tokyo, Japan
,
Takanori Kanai
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

submitted 02 September 2016

accepted after revision 13 March 2017

Publication Date:
04 May 2017 (eFirst)

Abstract

Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS.

Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0. The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤ 2) was also assessed.

Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86.

Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.

* These authors contributed equally to this work.