Endoscopy 2017; 49(06): 560-563
DOI: 10.1055/s-0043-106556
Innovations and brief communications
© Georg Thieme Verlag KG Stuttgart · New York

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Yoshihiro Nakazato*, 1, 2, Makoto Naganuma*, 1, Shinya Sugimoto1, Rieko Bessho3, Mari Arai1, Hiroki Kiyohara1, Keiko Ono1, Kosaku Nanki1, Makoto Mutaguchi1, Shinta Mizuno1, Taku Kobayashi1, Naoki Hosoe2, Masayuki Shimoda4, Takayuki Abe5, Nagamu Inoue3, Haruhiko Ogata2, Yasushi Iwao3, Takanori Kanai1
  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
  • 2Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan
  • 3Center for Preventive Medicine, Keio University School of Medicine, Tokyo, Japan
  • 4Department of Pathology, Keio University School of Medicine, Tokyo, Japan
  • 5Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan
Further Information

Publication History

submitted 02 September 2016

accepted after revision 13 March 2017

Publication Date:
04 May 2017 (eFirst)

Abstract

Background and study aim Endocytoscopy (ECS) is used in the in vivo microscopic inspection of microstructural mucosal features and enables endoscopists to assess the histological severity of ulcerative colitis (UC). The aim of this study was to assess histological healing in UC patients by using ECS.

Patients and methods A total of 64 patients in clinical and endoscopic remission who underwent ECS were selected. The correlation between the ECS score and Geboes score at the rectum was evaluated in patients with a Mayo endoscopic score (MES) of 0. The diagnostic accuracy of the ECS score for histological remission (Geboes score ≤ 2) was also assessed.

Results The ECS score ranged from 0 to 5 in patients with endoscopic remission on conventional white-light images (MES of 0). The agreement between histological remission regarding the ECS score and the Geboes score had a κ value of 0.72, and the ECS score showed high accuracy for histological remission, with a sensitivity of 0.77, a specificity of 0.97, and a diagnostic accuracy of 0.86.

Conclusion ECS can be used to assess histological healing in patients with UC without the need for biopsy specimens.

* These authors contributed equally to this work.