Zentralbl Chir 2017; 142(05): 502-505
DOI: 10.1055/s-0043-119998
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

PET-CT bei vaskulärem Graft-Infekt

PET-CT in Vascular Graft Infections
Lars Husmann
1   Abteilung für Nuklearmedizin, UniversitätsSpital Zürich, Schweiz
,
Barbara Hasse
2   Abteilung für Infektiologie, UniveritätsSpital Zürich, Schweiz
› Author Affiliations
Further Information

Publication History

Publication Date:
27 October 2017 (online)

Zusammenfassung

Die 18F-Fluordesoxyglukose-Positronenemissionstomografie-Computertomografie (FDG-PET-CT) hat eine hohe diagnostische Genauigkeit bei vaskulären Graft-Infekten. Auch bei Therapieverlaufskontrollen von Graft-Infekten scheint der Einsatz der FDG-PET-CT sinnvoll, da ein signifikanter Einfluss auf das Patientenmanagement gezeigt werden konnte; ergänzende Daten größerer Studien sind aktuell jedoch noch ausstehend.

Abstract

18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET-CT) exhibits high diagnostic accuracy in the detection of vascular graft infections. Therapy control in vascular graft infection with FDG-PET-CT appears to be useful, as a significant impact on patient management has been described; however, supplemental data from large outcome studies are still pending.

 
  • Literatur

  • 1 Schwarz JK, Grigsby PW, Dehdashti F. et al. The role of 18F-FDG PET in assessing therapy response in cancer of the cervix and ovaries. J Nucl Med 2009; 50 (Suppl. 01) S64-S73
  • 2 Goerres GW, Stupp R, Barghouth G. et al. The value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylate. Eur J Nucl Med Mol Imaging 2005; 32: 153-162
  • 3 Brucher BL, Weber W, Bauer M. et al. Neoadjuvant therapy of esophageal squamous cell carcinoma: response evaluation by positron emission tomography. Ann Surg 2001; 233: 300-309
  • 4 de Wit M, Bohuslavizki KH, Buchert R. et al. 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkinʼs lymphoma. Ann Oncol 2001; 12: 29-37
  • 5 Barnes JA, LaCasce AS, Zukotynski K. et al. End-of-treatment but not interim PET scan predicts outcome in nonbulky limited-stage Hodgkinʼs lymphoma. Ann Oncol 2011; 22: 910-915
  • 6 Granados U, Fuster D, Pericas JM. et al. Diagnostic accuracy of 18F-FDG PET/CT in infective endocarditis and implantable cardiac electronic device infection: a cross-sectional study. J Nucl Med 2016; 57: 1726-1732
  • 7 Basu S, Chryssikos T, Moghadam-Kia S. et al. Positron emission tomography as a diagnostic tool in infection: present role and future possibilities. Semin Nucl Med 2009; 39: 36-51
  • 8 Hasse B, Husmann L, Zinkernagel A. et al. Vascular graft infections. Swiss Med Wkly 2013; 143: w13754
  • 9 Israel O, Keidar Z. PET/CT imaging in infectious conditions. Ann N Y Acad Sci 2011; 1228: 150-166
  • 10 Sah BR, Husmann L, Mayer D. et al. Diagnostic performance of 18F-FDG-PET/CT in vascular graft infections. Eur J Vasc Endovasc Surg 2015; 49: 455-464
  • 11 Saleem BR, Beukinga RJ, Boellaard R. et al. Textural features of 18F-fluorodeoxyglucose positron emission tomography scanning in diagnosing aortic prosthetic graft infection. Eur J Nucl Med Mol Imaging 2017; 44: 886-894
  • 12 Husmann L, Sah BR, Scherrer A. et al. 18F-FDG PET/CT for therapy control in vascular graft infections: a first feasibility study. J Nucl Med 2015; 56: 1024-1029
  • 13 Fukuchi K, Ishida Y, Higashi M. et al. Detection of aortic graft infection by fluorodeoxyglucose positron emission tomography: comparison with computed tomographic findings. J Vasc Surg 2005; 42: 919-925
  • 14 Keidar Z, Engel A, Hoffman A. et al. Prosthetic vascular graft infection: the role of 18F-FDG PET/CT. J Nucl Med 2007; 48: 1230-1236
  • 15 Spacek M, Belohlavek O, Votrubova J. et al. Diagnostics of “non-acute” vascular prosthesis infection using 18F-FDG PET/CT: our experience with 96 prostheses. Eur J Nucl Med Mol Imaging 2009; 36: 850-858
  • 16 Bruggink JL, Glaudemans AW, Saleem BR. et al. Accuracy of FDG-PET-CT in the diagnostic work-up of vascular prosthetic graft infection. Eur J Vasc Endovasc Surg 2010; 40: 348-354
  • 17 Tokuda Y, Oshima H, Araki Y. et al. Detection of thoracic aortic prosthetic graft infection with 18F-fluorodeoxyglucose positron emission tomography/computed tomography. Eur J Cardiothorac Surg 2013; 43: 1183-1187
  • 18 Pfannenberg AC, Aschoff P, Brechtel K. et al. Value of contrast-enhanced multiphase CT in combined PET/CT protocols for oncological imaging. Br J Radiol 2007; 80: 437-445
  • 19 Rabkin Z, Israel O, Keidar Z. Do hyperglycemia and diabetes affect the incidence of false-negative 18F-FDG PET/CT studies in patients evaluated for infection or inflammation and cancer? A comparative analysis. J Nucl Med 2010; 51: 1015-1020
  • 20 Kagna O, Kurash M, Ghanem-Zouabi N. et al. Does antibiotic treatment affect the diagnostic accuracy of FDG PET/CT studies in patients with suspected infectious processes?. J Nucl Med 2017; DOI: 10.2967/jnumed.117.192062. [Epub ahead of print]
  • 21 Wyss MT, Honer M, Späth N. et al. Influence of ceftriaxone treatment on FDG uptake–an in vivo [18F]-fluorodeoxyglucose imaging study in soft tissue infections in rats. Nucl Med Biol 2004; 31: 875-882
  • 22 Both M, Ahmadi-Simab K, Reuter M. et al. MRI and FDG-PET in the assessment of inflammatory aortic arch syndrome in complicated courses of giant cell arteritis. Ann Rheum Dis 2008; 67: 1030-1033
  • 23 Machelart I, Greib C, Wirth G. et al. Graft infection after a Bentall procedure: a case series and systematic review of the literature. Diagn Microbiol Infect Dis 2017; 88: 158-162