CC BY 4.0 · J Brachial Plex Peripher Nerve Inj 2023; 18(01): e10-e20
DOI: 10.1055/s-0043-1764352
Review Article

Patient-Reported Outcomes and Provocative Testing in Peripheral Nerve Injury and Recovery

1   Texas Tech University Health Sciences Center, Lubbock, Texas
,
Stephen Rossettie
1   Texas Tech University Health Sciences Center, Lubbock, Texas
,
John Rafael
1   Texas Tech University Health Sciences Center, Lubbock, Texas
,
Cameron T. Cox
1   Texas Tech University Health Sciences Center, Lubbock, Texas
,
Ivica Ducic
2   Washington Nerve Institute, McLean, Virginia
,
Brendan J. Mackay
1   Texas Tech University Health Sciences Center, Lubbock, Texas
› Author Affiliations

Abstract

Background Peripheral nerve function is often difficult to assess given the highly variable presentation and subjective patient experience of nerve injury. If nerve assessment is incomplete or inaccurate, inappropriate diagnosis and subsequent treatment may result in permanent dysfunction.

Objective As our understanding of nerve repair and generation evolves, so have tools for evaluating peripheral nerve function, recovery, and nerve-related impact on the quality of life. Provocative testing is often used in the clinic to identify peripheral nerve dysfunction. Patient-reported outcome forms provide insights regarding the effect of nerve dysfunction on daily activities and quality of life.

Methods We performed a review of the literature using a comprehensive combination of keywords and search algorithms to determine the clinical utility of different provocative tests and patient-reported outcomes measures in a variety of contexts, both pre- and postoperatively.

Results This review may serve as a valuable resource for surgeons determining the appropriate provocative testing tools and patient-reported outcomes forms to monitor nerve function both pre- and postoperatively.

Conclusion As treatments for peripheral nerve injury and dysfunction continue to improve, identifying the most appropriate measures of success may ultimately lead to improved patient outcomes.

Author Contributions

A.J. was responsible for conceptualization, investigation, project administration, and writing. S.R. was responsible for investigation and writing. J.R. was responsible for investigation and writing. C.T.C. was responsible for conceptualization, project administration, and writing. I.D. was responsible for supervision and validation. B.M. was responsible for conceptualization and validation.




Publication History

Received: 07 August 2022

Accepted: 03 February 2023

Article published online:
21 April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Stassart RM, Fledrich R, Velanac V. et al. A role for Schwann cell-derived neuregulin-1 in remyelination. Nat Neurosci 2013; 16 (01) 48-54
  • 2 Chung KC, Yoneda H. Surgical management of severe upper extremity injury. UpToDate 2019
  • 3 Vargas ME, Barres BA. Why is Wallerian degeneration in the CNS so slow?. Annu Rev Neurosci 2007; 30: 153-179
  • 4 Echeverry S, Wu Y, Zhang J. Selectively reducing cytokine/chemokine expressing macrophages in injured nerves impairs the development of neuropathic pain. Exp Neurol 2013; 240: 205-218
  • 5 Lundborg G, Myers R, Powell H. Nerve compression injury and increased endoneurial fluid pressure: a “miniature compartment syndrome”. J Neurol Neurosurg Psychiatry 1983; 46 (12) 1119-1124
  • 6 Bogle A, Wiesler E. Neuritis of the cutaneous nerves of the hand. J Hand Surg Am 2014; 39 (06) 1204-1206
  • 7 Menorca RMG, Fussell TS, Elfar JC. Nerve physiology: mechanisms of injury and recovery. Hand Clin 2013; 29 (03) 317-330
  • 8 Baltodano PA, Tong AJ, Chhabra A, Rosson GD. The role of magnetic resonance neurography in the postoperative management of peripheral nerve injuries. Neuroimaging Clin N Am 2014; 24 (01) 235-244
  • 9 Martín Noguerol T, Barousse R, Gómez Cabrera M, Socolovsky M, Bencardino JT, Luna A. Functional MR neurography in evaluation of peripheral nerve trauma and postsurgical assessment. Radiographics 2019; 39 (02) 427-446
  • 10 Alvites R, Rita Caseiro A, Santos Pedrosa S. et al. Peripheral nerve injury and axonotmesis: state of the art and recent advances. Cogent Med 2018; 5 (01) 1466404
  • 11 Papatheodorou LK, Williams BG, Sotereanos DG. Preliminary results of recurrent cubital tunnel syndrome treated with neurolysis and porcine extracellular matrix nerve wrap. J Hand Surg Am 2015; 40 (05) 987-992
  • 12 Gaspar MP, Abdelfattah HM, Welch IW, Vosbikian MM, Kane PM, Rekant MS. Recurrent cubital tunnel syndrome treated with revision neurolysis and amniotic membrane nerve wrapping. J Shoulder Elbow Surg 2016; 25 (12) 2057-2065
  • 13 Tos P, Crosio A, Pugliese P, Adani R, Toia F, Artiaco S. Painful scar neuropathy: principles of diagnosis and treatment. Plast Aesthet Res 2015; 2: 156-164
  • 14 Ingram LA, Butler AA, Walsh LD, Brodie MA, Lord SR, Gandevia SC. The upper limb physiological profile assessment: description, reliability, normative values and criterion validity. PLoS One 2019; 14 (06) e0218553
  • 15 Wang Y, Sunitha M, Chung KC. How to measure outcomes of peripheral nerve surgery. Hand Clin 2013; 29 (03) 349-361
  • 16 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg 2021; 88: 105906
  • 17 Ho T, Braza ME. Hoffmann Tinel Sign. StatPearls. StatPearls Publishing Copyright © 2020, StatPearls Publishing LLC.; 2020
  • 18 Davis EN, Chung KC. The Tinel sign: a historical perspective. Plast Reconstr Surg 2004; 114 (02) 494-499
  • 19 Ho T, Braza ME. Hoffmann Tinel Sign. 2020 [available at: https://www.ncbi.nlm.nih.gov/books/NBK555934/]
  • 20 MacDermid JC, Doherty T. Clinical and electrodiagnostic testing of carpal tunnel syndrome: a narrative review. J Orthop Sports Phys Ther 2004; 34 (10) 565-588
  • 21 Phalen GS. Spontaneous compression of the median nerve at the wrist. J Am Med Assoc 1951; 145 (15) 1128-1133
  • 22 Kuschner SH, Ebramzadeh E, Johnson D, Brien WW, Sherman R. Tinel's sign and Phalen's test in carpal tunnel syndrome. Orthopedics 1992; 15 (11) 1297-1302
  • 23 MacDermid JC, Wessel J. Clinical diagnosis of carpal tunnel syndrome: a systematic review. J Hand Ther 2004; 17 (02) 309-319
  • 24 Durkan JA. A new diagnostic test for carpal tunnel syndrome. J Bone Joint Surg Am 1991; 73 (04) 535-538
  • 25 Szabo RM, Slater Jr RR, Farver TB, Stanton DB, Sharman WK. The value of diagnostic testing in carpal tunnel syndrome. J Hand Surg Am 1999; 24 (04) 704-714
  • 26 Cheng CJ, Mackinnon-Patterson B, Beck JL, Mackinnon SE. Scratch collapse test for evaluation of carpal and cubital tunnel syndrome. J Hand Surg Am 2008; 33 (09) 1518-1524
  • 27 Montgomery K, Wolff G, Boyd KU. Evaluation of the scratch collapse test for carpal and cubital tunnel syndrome—a prospective, blinded study. J Hand Surg Am 2020; 45 (06) 512-517
  • 28 Huynh MNQ, Karir A, Bennett A. Scratch collapse test for carpal tunnel syndrome: a systematic review and meta-analysis. Plast Reconstr Surg Glob Open 2018; 6 (09) e1933
  • 29 Kahn LC, Yee A, Mackinnon SE. Important details in performing and interpreting the scratch collapse test. Plast Reconstr Surg 2018; 141 (02) 399-407
  • 30 Henry SL, Ring DC. Discussion: important details in performing and interpreting the scratch collapse test. Plast Reconstr Surg 2018; 141 (02) 408-409
  • 31 Gillenwater J, Cheng J, Mackinnon SE. Evaluation of the scratch collapse test in peroneal nerve compression. Plast Reconstr Surg 2011; 128 (04) 933-939
  • 32 MacDermid JC. Measurement of health outcomes following tendon and nerve repair. J Hand Ther 2005; 18 (02) 297-312
  • 33 Fonseca MCR, Elui VMC, Lalone E. et al. Functional, motor, and sensory assessment instruments upon nerve repair in adult hands: systematic review of psychometric properties. Syst Rev 2018; 7 (01) 175
  • 34 Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30 (06) 473-483
  • 35 LoMartire R, Äng BO, Gerdle B, Vixner L. Psychometric properties of Short Form-36 Health Survey, EuroQol 5-dimensions, and Hospital Anxiety and Depression Scale in patients with chronic pain. Pain 2020; 161 (01) 83-95
  • 36 Bunevicius A. Reliability and validity of the SF-36 Health Survey Questionnaire in patients with brain tumors: a cross-sectional study. Health Qual Life Outcomes 2017; 15 (01) 92
  • 37 White MK, McCausland KL, Sanchorawala V, Guthrie SD, Bayliss MS. Psychometric validation of the SF-36 Health Survey in light chain amyloidosis: results from community-based and clinic-based samples. Patient Relat Outcome Meas 2017; 8: 157-167
  • 38 Ware Jr JE. SF-36 health survey update. Spine 2000; 25 (24) 3130-3139
  • 39 Stratford P, Gill C, Westaway M, Binkley JM. Assessing disability and change on individual patients: a report of a patient specific measure. Physiother Can 1995; 47: 258-263
  • 40 Novak CB, von der Heyde RL. Evidence and techniques in rehabilitation following nerve injuries. Hand Clin 2013; 29 (03) 383-392
  • 41 Chatman AB, Hyams SP, Neel JM. et al. The patient-specific functional scale: measurement properties in patients with knee dysfunction. Phys Ther 1997; 77 (08) 820-829
  • 42 Horn KK, Jennings S, Richardson G, Vliet DV, Hefford C, Abbott JH. The patient-specific functional scale: psychometrics, clinimetrics, and application as a clinical outcome measure. J Orthop Sports Phys Ther 2012; 42 (01) 30-42
  • 43 Hudak PL, Amadio PC, Bombardier C. The Upper Extremity Collaborative Group (UECG). Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. Am J Ind Med 1996; 29 (06) 602-608
  • 44 Beaton DE, Wright JG, Katz JN. Upper Extremity Collaborative Group. Development of the QuickDASH: comparison of three item-reduction approaches. J Bone Joint Surg Am 2005; 87 (05) 1038-1046
  • 45 Novak CB, Anastakis DJ, Beaton DE, Mackinnon SE, Katz J. Relationships among pain disability, pain intensity, illness intrusiveness, and upper extremity disability in patients with traumatic peripheral nerve injury. J Hand Surg Am 2010; 35 (10) 1633-1639
  • 46 Smith MV, Calfee RP, Baumgarten KM, Brophy RH, Wright RW. Upper extremity-specific measures of disability and outcomes in orthopaedic surgery. J Bone Joint Surg Am 2012; 94 (03) 277-285
  • 47 Oksüz C, Akel BS, Leblebicioğlu G, Kayıhan H. Which hand outcome measurement is best for Turkish speaking patients?. Acta Orthop Traumatol Turc 2012; 46 (02) 83-88
  • 48 Gabel CP, Michener L, Melloh M, Cuesta-Vargas A. The psychometric properties of the dash and quickdash. J Orthop Sports Phys Ther 2015; 45 (05) 426-427
  • 49 Ceiling Effect SN. Encyclopedia of Research Design. 2010. :chap 8
  • 50 Forget NJ, Jerosch-Herold C, Shepstone L, Higgins J. Psychometric evaluation of the Disabilities of the Arm, Shoulder and Hand (DASH) with Dupuytren's contracture: validity evidence using Rasch modeling. BMC Musculoskelet Disord 2014; 15 (01) 361
  • 51 Ducic I, Fu R, Iorio ML. Innovative treatment of peripheral nerve injuries: combined reconstructive concepts. Ann Plast Surg 2012; 68 (02) 180-187
  • 52 Chung KC, Pillsbury MS, Walters MR, Hayward RA. Reliability and validity testing of the Michigan Hand Outcomes Questionnaire. J Hand Surg Am 1998; 23 (04) 575-587
  • 53 Busuioc SA, Karim M, Bourbonnais D. et al. Cross-cultural adaptation, validity, reliability and clinical applicability of the Michigan Hand Outcomes Questionnaire, and its Brief Version, to Canadian French. J Hand Ther 2018; 31 (01) 145-146
  • 54 Shauver MJ, Chung KC. The Michigan hand outcomes questionnaire after 15 years of field trial. Plast Reconstr Surg 2013; 131 (05) 779e-787e
  • 55 Nolte MT, Shauver MJ, Chung KC. Normative values of the michigan hand outcomes questionnaire for patients with and without hand conditions. Plast Reconstr Surg 2017; 140 (03) 425e-433e
  • 56 Levine DW, Simmons BP, Koris MJ. et al. A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome. J Bone Joint Surg Am 1993; 75 (11) 1585-1592
  • 57 Leite JC, Jerosch-Herold C, Song F. A systematic review of the psychometric properties of the Boston Carpal Tunnel Questionnaire. BMC Musculoskelet Disord 2006; 7 (01) 78
  • 58 Atroshi I, Lyrén P-E, Gummesson C. The 6-item CTS symptoms scale: a brief outcomes measure for carpal tunnel syndrome. Qual Life Res 2009; 18 (03) 347-358
  • 59 Grandizio LC, Boualam B, Shea P. et al. The reliability of the CTS-6 for examiners with varying levels of clinical experience. J Hand Surg Am 2022; 47 (06) 501-506
  • 60 Craw JR, Church DJ, Hutchison RL. Prospective comparison of the six-item carpal tunnel symptoms scale and portable nerve conduction testing in measuring the outcomes of treatment of carpal tunnel syndrome with steroid injection. Hand (N Y) 2015; 10 (01) 49-53
  • 61 Multanen J, Ylinen J, Karjalainen T, Ikonen J, Häkkinen A, Repo JP. Structural validity of the Boston Carpal Tunnel Questionnaire and its short version, the 6-Item CTS symptoms scale: a Rasch analysis one year after surgery. BMC Musculoskelet Disord 2020; 21 (01) 609
  • 62 Wouters RM, Jobi-Odeneye AO, de la Torre A, Joseph A, Hovius SER. ICHOM Hand and Wrist Working Group. A standard set for outcome measurement in patients with hand and wrist conditions: consensus by the International Consortium for Health Outcomes Measurement Hand and Wrist Working Group. J Hand Surg Am 2021; 46 (10) 841-855