Endoscopy 2023; 55(S 02): S229-S230
DOI: 10.1055/s-0043-1765614
Abstracts | ESGE Days 2023
ePoster

Does Helicobacter Pylori Eradication Improve Parameters In Non-alcoholic Fatty Liver Disease?: A Systematic Review And Meta-analysis of The Randomized Controlled Trials

Authors

  • F. Jaber

    1   University of Missouri-Kansas City Volker Campus, Kansas City, United States of America

  • S. Alsakarneh

    2   University of Missouri-Kansas City: Hospital Hill Campus, Kansas City, United States of America

  • H. Ghoz

    1   University of Missouri-Kansas City Volker Campus, Kansas City, United States of America
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Aims The correlation between eradication of Helicobacter pylori and parameters of non-alcoholic fatty liver disease (NAFLD) remains controversial. This meta-analysis aims to examine the effect of HP treatment on fibrosis, metabolic and anthropometric parameters and to compare its effect with lifestyle changes alone.

Methods We conducted a literature search through October 2022, for all randomized controlled trials (RCTs) comparing the effect of HP treatment among NAFLD patients. Primary outcome was the change in fibrosis parameters (liver fat content and controlled accentuated parameters (CAP)). Secondary endpoints included changes in body mass index (BMI), body weight, waist circumference, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), (ALT), (AST), and lipid profile. The random effects model was used to calculate the standardized mean difference (SMD) with 95% confidence intervals (CI).

Results 4 RCTs were included. H. pylori Eradication was associated with a significant decrease in FBG, and ALT values compared to those with lifestyle changes alone. There was a trend toward decrease in fibrosis parameters , but this was not statistically significant ([Table 1]). There was no significant difference in BMI, body weight, waist circumference, HOMA-IR, AST, TGL, HDL, LDL, and TC.

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Table 1  Forest post comparing changes in A) Anthropometric parameters: BMI-Weight-Waist Circumference B) Fibrosis Parameters C) Metabolic parameters: FBG-HOM-IR-ALT-AST.

Conclusions Our study showed that the eradication of HP could considerably improve the ALT index and fasting blood glucose. There was a trend toward decrease in fibrosis indicators but was not statistically significant likely due to small sample size. Additional RCTs with larger sample size and longer follow-up are required to validate our results.



Publication History

Article published online:
14 April 2023

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