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DOI: 10.1055/s-0043-1769496
Association between Benign Paroxysmal Positional Vertigo and Thyroid Diseases: Systematic Review and Meta-Analysis
Funding Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 28001010072P3.
Abstract
Introduction Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular dysfunction that most affects people worldwide, but its etiopathogenesis is still not fully understood. Considering the etiological diversity, some studies highlight the association between BPPV and thyroid diseases.
Objective To investigate the association between thyroid diseases and BPPV.
Data Synthesis Systematic review and meta-analysis of epidemiological studies searched in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases. Studies that were fully available and investigated the association between BPPV and thyroid diseases were selected. The articles that composed the meta-analysis were analyzed using the dichotomous model, the Mantel-Haenszel statistical test, odds ratio (OR), and a 95% confidence interval (CI). Of the 67 articles retrieved from the databases, 7 met the eligibility criteria of the systematic review, and 4 had data necessary to perform the meta-analysis. Qualitative analysis revealed that the studies were conducted in the European and Asian continents. The predominant methodological design was the case-control type, and thyroid dysfunctions, hypothyroidism, and Hashimoto thyroiditis occurred more frequently. The meta-analysis showed no association between hypothyroidism and BPPV; however, there was a statistically significant relationship between Hashimoto thyroiditis and BPPV.
Conclusion The meta-analysis results suggest a possible association between BPPV and Hashimoto thyroiditis. Nevertheless, we emphasize the need for further studies to elucidate the evidence obtained.
Keywords
benign paroxysmal positional vertigo - hypothyroidism - hyperthyroidism - hashimoto thyroiditisThe present article is part of Cyntia Machado Lima's master's dissertation, presented on 04/01/2022
Publication History
Received: 06 January 2023
Accepted: 12 March 2023
Article published online:
14 September 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Cousins S, Kaski D, Cutfield N. et al. Vestibular perception following acute unilateral vestibular lesions. PLoS One 2013; 8 (05) e61862 DOI: 10.1371/journal.pone.0061862.
- 2 von Brevern M, Bertholon P, Brandt T. et al. Benign paroxysmal positional vertigo: Diagnostic criteria. J Vestib Res 2015; 25 (3-4): 105-117 DOI: 10.3233/VES-150553.
- 3 von Brevern M, Radtke A, Lezius F. et al. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry 2007; 78 (07) 710-715 DOI: 10.1136/jnnp.2006.100420.
- 4 Kim HJ, Park J, Kim JS. Update on benign paroxysmal positional vertigo. J Neurol 2021; 268 (05) 1995-2000 DOI: 10.1007/s00415-020-10314-7.
- 5 Kim HJ, Lee JO, Choi JY, Kim JS. Etiologic distribution of dizziness and vertigo in a referral-based dizziness clinic in South Korea. J Neurol 2020; 267 (08) 2252-2259 DOI: 10.1007/s00415-020-09831-2.
- 6 Yang X, Yang B, Wu M. et al. Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. Front Neurol 2019; 10: 91 DOI: 10.3389/fneur.2019.00091.
- 7 Yuan J, Dai J, Li WA, Hu W. Factors Associated with Benign Paroxysmal Positional Vertigo: A Chinese Case-Control Study. Med Sci Monit 2017; 23: 3885-3889 DOI: 10.12659/msm.9057169.
- 8 Sari K, Yildirim T, Borekci H, Akin I, Aydin R, Ozkiris M. The relationship between benign paroxysmal positional vertigo and thyroid autoimmunity. Acta Otolaryngol 2015; 135 (08) 754-757 DOI: 10.3109/00016489.2015.1021932.
- 9 Neuhauser HK. The epidemiology of dizziness and vertigo. Handb Clin Neurol 2016; 137: 67-82 DOI: 10.1016/B978-0-444-63437-5.00005-4.
- 10 Papi G, Corsello SM, Milite MT. et al. Association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis. Clin Endocrinol (Oxf) 2009; 70 (01) 169-170 DOI: 10.1111/j.1365-2265.2008.03311.x.
- 11 Papi G, Guidetti G, Corsello SM, Di Donato C, Pontecorvi A. The association between benign paroxysmal positional vertigo and autoimmune chronic thyroiditis is not related to thyroid status. Thyroid 2010; 20 (02) 237-238 DOI: 10.1089/thy.2009.0319.
- 12 Modugno GC, Pirodda A, Ferri GG, Montana T, Rasciti L, Ceroni AR. A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo?. Med Hypotheses 2000; 54 (04) 614-615 DOI: 10.1054/mehy.1999.0905.
- 13 Wajchenberg BL, Lerario AC, Betti RTB. Tireoide. In: Gen, ed. Tratato de Endocrinologia Clínica. 2. ed. São Paulo; 2014: 155-311
- 14 Sales P, Marcon LP. Tireoide. In: Roca, ed. O essencial em endocrinologia. 1. ed.. Rio de Janeiro; 2016: 768-938
- 15 Vilar L. et al. Doenças da Tireoide. In: Guanabara Koogan, ed. Endocrinologia Clínica. 6. ed.. Rio de Janeiro; 2016: 389-496
- 16 Honório HM, Santiago JF. Fundamentos das Revisões Sistemáticas em Saúde. São Paulo: Santos Pub; 2021: 608
- 17 Carvalho APV, Silva V, Grande AJ. Avaliação do risco de viés de ensaios clínicos randomizados pela ferramenta da colaboração Cochrane. Diagn. tratamento 2013; 18 (01) 38-44 Available from: URL: http://files.bvs.br/upload/S/1413-9979/2013/v18n1/a3444.pdf
- 18 Wells GA, Shea B, O'Connell D. et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. Available from: URL: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp [cited 2009 Oct 19]
- 19 Draghi TTG, Cavalcante Neto JL, Rohr LA, Jelsma LD, Tudella E. Symptoms of anxiety and depression in children with developmental coordination disorder: a systematic review. J Pediatr (Rio J) 2020; 96 (01) 8-19 DOI: 10.1016/j.jped.2019.03.002.
- 20 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372 (71) n71 DOI: 10.1136/bmj.n71.
- 21 Moher D, Shamseer L, Clarke M. et al; PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015; 4 (01) 1 DOI: 10.1186/2046-4053-4-1.
- 22 Choi HG, Song YS, Wee JH, Min C, Yoo DM, Kim SY. Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study. Diagnostics (Basel) 2021; 11 (02) 329 DOI: 10.3390/diagnostics11020329.
- 23 Chiarella G, Tognini S, Nacci A. et al. Vestibular disorders in euthyroid patients with Hashimoto's thyroiditis: role of thyroid autoimmunity. Clin Endocrinol (Oxf) 2014; 81 (04) 600-605 DOI: 10.1111/cen.12471.
- 24 Turgay Yıldırım Ö, Kaya Ş, Baloğlu Kaya F. Evaluation of the Tp-e interval and Tp-e/QTc ratio in patients with benign paroxysmal positional vertigo in the emergency department compared with the normal population. J Electrocardiol 2020; 58: 51-55 DOI: 10.1016/j.jelectrocard.2019.11.002.
- 25 Hsu CL, Tsai SJ, Shen CC, Lu T, Hung YM, Hu LY. Risk of benign paroxysmal positional vertigo in patients with depressive disorders: a nationwide population-based cohort study. BMJ Open 2019; 9 (03) e026936 DOI: 10.1136/bmjopen-2018-026936.
- 26 Lautermann J, ten Cate WJ. Postnatal expression of the alpha-thyroid hormone receptor in the rat cochlea. Hear Res 1997; 107 (1-2): 23-28 DOI: 10.1016/s0378-5955(97)00014-2.
- 27 Iqbal AA, Burgess EH, Gallina DL, Nanes MS, Cook CB. Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis. Endocr Pract 2003; 9 (06) 517-521 DOI: 10.4158/EP.9.6.517.