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CC BY 4.0 · Rev Bras Ginecol Obstet 2023; 45(05): 293-296
DOI: 10.1055/s-0043-1770142
Febrasgo Position Statement

Cervical cancer in pregnancy

Number 5 – May 2023
Geórgia Fontes Cintra 
1   Instituto Brasileiro de Controle de Câncer, São Camilo Oncologia, São Paulo, SP, Brazil
,
Sophie Françoise Mauricette Derchain 
2   Universidade Estadual de Campinas, Campinas, SP, Brazil
,
Delzio Salgado Bicalho 
3   Instituto Oncoclínicas, Belo Horizonte, MG, Brazil
,
Agnaldo Lopes da Silva Filho 
4   Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
,
Walquíria Quida Salles Pereira Primo 
5   Universidade de Brasília, Brasília, DF, Brazil
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Key points

  • The incidence of cancer during pregnancy has increased given women's tendency to delay pregnancy. Cervical cancer is the third most commonly diagnosed neoplasm during pregnancy.

  • Screening and diagnosis should be performed as in non-pregnant patients; cervical cytology is an obligatory antenatal exam, and colposcopy with biopsy may be performed at any time of pregnancy.

  • Pregnancies complicated by the diagnosis of cancer should always be carried out in a reference center by a multidisciplinary team.

  • The termination of pregnancy for standard treatment in specific situations is supported by law.

  • Neoadjuvant chemotherapy is a safe alternative treatment during pregnancy to allow reaching fetal maturity. Response rates are high and neoplastic progression during pregnancy is reported in only 2.9% of cases. The risk of fetal malformations from chemotherapy is similar to that of the general population. However, chemotherapy is associated with intrauterine growth restriction, low birth weight, and neonatal myelotoxicity.

  • In the absence of disease progression, the pregnancy should be carried to term.

The National Commission Specialized in Gynecology Oncology of the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) endorses this document. The production of content is based on scientific evidence on the proposed theme and the results presented contribute to clinical practice.




Publication History

Article published online:
20 June 2023

© 2023. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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