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Clin Colon Rectal Surg 2024; 37(03): 127-132
DOI: 10.1055/s-0043-1770380
Review Article

The Natural History of Hereditary Colorectal Cancer Syndromes: From Phenotype to Genotype? Where Do We Stand and What Does the Future Hold?

James Church
1   Division of Colorectal Surgery, Department of Surgery, Columbia University Medical Center, New York, New York
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Abstract

Applying the concept of a “natural history” to hereditary colorectal cancer is an interesting exercise because the way the syndromes are approached has changed so drastically. However, the exercise is instructive as it forces us to think in depth about where we are, where we have been, and, most helpfully, about where we may be going. In this article the diagnosis, along with endoscopic and surgical management of hereditary colorectal cancer are discussed in the context of their history and the changes in genomics and technology that have occurred over the last one hundred years.

Keywords

hereditary colorectal cancer - molecular genetics of colorectal cancer


Publication History

Article published online:
09 August 2023

© 2023. Thieme. All rights reserved.

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