Synlett 2025; 36(02): 151-156
DOI: 10.1055/s-0043-1774864
letter

A Convergent Approach to the Forskolin Skeleton

Fortune O. Ononiwu
,
Bo Wang
,

Support of this work by the National Institutes of Health (R01 GM-4357) and Syracuse University is gratefully acknowledged.


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Abstract

A convergent approach to the forskolin skeleton is described. Assembly of a simplified tricyclic framework is achieved in a single step via the dihydropyrone Diels–Alder reaction. Selective manipulation of the resulting cycloadduct, in conjunction with an unusual equilibration of the C8 stereocenter, provides access to scaffolds that differ in relative stereochemistry at both the A/B and B/C ring junctions.

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Publication History

Received: 06 March 2024

Accepted after revision: 23 April 2024

Article published online:
06 May 2024

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