Synlett 2025; 36(16): 2573-2576
DOI: 10.1055/s-0043-1775478
letter
Small Molecules in Medicinal Chemistry

Reactive Probe for Fluorescent Detection of Norepinephrine Based On an Excited-State Intramolecular Proton Transfer (ESIPT) Mechanism

Authors

  • Rajibul Haque

    a   Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India
    c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Souma Ghosh

    b   Department of Oils, Lipid Science &Technology, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India
    c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Rajkumar Banerjee

    b   Department of Oils, Lipid Science &Technology, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India
    c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Debabrata Maity

    a   Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India
    c   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

D.M. gratefully acknowledges the Director of the Council of Scientific and Industrial Research - Indian Institute of Chemical Technology (CSIR-IICT), India (MLP0108) and the Science and Engineering Research Board (SERB), India (SRG/2023/001243) for funding. The IICT Communication No. for this manuscript is IICT/Pubs./2025/028.


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Abstract

Norepinephrine is a key neurotransmitter that plays a critical role in the sympathetic nervous system. Its misuse and lack of regulation is closely associated with the progression of different central nervous system syndromes and neurodegenerative disorders. Herein, a reactive probe based on an excited-state intramolecular proton transfer (ESIPT) mechanism is reported for the selective fluorescent detection of norepinephrine under physiological conditions and in live cells.

Supporting Information



Publication History

Received: 25 January 2025

Accepted after revision: 28 March 2025

Article published online:
14 May 2025

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