Reactive Probe for Fluorescent Detection of Norepinephrine Based On an Excited-State Intramolecular Proton Transfer (ESIPT) Mechanism

Abstract

Norepinephrine is a key neurotransmitter that plays a critical role in the sympathetic nervous system. Its misuse and lack of regulation is closely associated with the progression of different central nervous system syndromes and neurodegenerative disorders. Herein, a reactive probe based on an excited-state intramolecular proton transfer (ESIPT) mechanism is reported for the selective fluorescent detection of norepinephrine under physiological conditions and in live cells.

Key words

fluorescent probes - norepinephrine - excited-state intramolecular proton transfer - 2-(2′-hydroxyphenyl)benzothiazole - Live-cell imaging

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