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DOI: 10.1055/s-0043-1777293
Juvenile Nasopharyngeal Angiofibroma: A Series of 96 Surgical Cases
Funding The authors declare that they have received no financial support from agencies in the public, private or non-profit sectors to conduct the present research.Abstract
Introduction Juvenile nasopharyngeal angiofibroma (JNA) is a benign vascularized tumor that affects almost exclusively male adolescents. Surgery is the treatment of choice for JNA.
Objectives The present study is a 42-year retrospective review of a series of JNA cases treated surgically without previous embolization.
Methods The present is a retrospective, descriptive study based on medical records of 96 patients with JNA who underwent microscopic or endoscopic excision without previous embolization from 1978 to 2020 in a single institution. The patients were categorized according to the Andrews et al. stage, and data were collected on age, gender, tumor staging, surgical approach, affected side, and outcome.
Results All patients were male, with an average age of 17 years. The predominant tumor stage consisted of type II, with 52.1%. A total of 33.3% of the patients were submitted to the microscopic technique and 66.7%, to the endonasal technique. The rate of intraoperative blood transfusion was of 17.7%.
Conclusion The present study reinforces that resection of JNA in various stages is viable without previous artery embolization.
Publication History
Received: 25 October 2022
Accepted: 15 October 2023
Article published online:
04 June 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Diaz A, Wang E, Bujnowski D. et al. Embolization in Juvenile Nasopharyngeal Angiofibroma Surgery: A Systematic Review and Meta-Analysis. Laryngoscope 2023; 133 (07) 1529-1539 DOI: 10.1002/lary.30616.
- 2 Marshall C, Agosti E, Peris-Celda M, Pinheiro-Neto CD. Combined endoscopic endonasal and sublabial transmaxillary approaches for resection of intracranially extended juvenile nasopharyngeal angiofibroma. Acta Neurochir (Wien) 2023; 165 (07) 1773-1780 DOI: 10.1007/s00701-023-05634-2.
- 3 Crisol-Deza DA, Bendezú-Huasasquiche LE. Angiofibroma nasofaríngeo juvenil. Rev Mex Pediatr. 2022; 89 (02) 63-67 DOI: 10.35366/107500.
- 4 Szyfter W, Balcerowiak A, Gawęcki W, Juszkat R, Wierzbicka M. Juvenile nasopharyngeal angiofibroma-20 years of experience in endoscopic treatment. Otolaryngol Pol 2021; 75 (02) 9-14 DOI: 10.5604/01.3001.0014.5220.
- 5 Lao WP, Lagabon KJ, Arom GA, Walker PC, Lee SC. Combined endoscopic and transoral resection of a high-staged juvenile nasopharyngeal angiofibroma: A pictorial essay. Head Neck 2021; 43 (02) 719-724 DOI: 10.1002/hed.26516.
- 6 Maroda AJ, Beckmann NA, Sheyn AM. et al. Trimodal embolization of juvenile nasopharyngeal angiofibroma with intracranial extension. Int J Pediatr Otorhinolaryngol 2020; 130: 109805 DOI: 10.1016/j.ijporl.2019.109805.
- 7 Oré Acevedo JF, La Torre Caballero LM, Urteaga Quiroga RJ. Tratamiento quirúrgico del angiofibroma nasofaríngeo juvenil en pacientes pediátricos. Acta Otorrinolaringol Esp (Engl Ed) 2019; 70 (05) 279-285
- 8 Sousa S, Patrão F, Pereira G, Monteiro E. Juvenile nasopharyngeal angiofibroma: A retrospective study of 27 cases in the ENT department of IPO-PORTO. Clin Otolaryngol 2019; 44 (03) 456-460 DOI: 10.1111/coa.13309.
- 9 Janakiram TN, Sharma SB, Panicker VB. Endoscopic excision of non-embolized juvenile nasopharyngeal angiofibroma: our technique. Indian J Otolaryngol Head Neck Surg 2016; 68 (03) 263-269
- 10 Langdon C, Herman P, Verillaud B. et al. Expanded endoscopic endonasal surgery for advanced stage juvenile angiofibromas: a retrospective multi-center study. Rhinology 2016; 54 (03) 239-246
- 11 Liu Z, Hua W, Zhang H. et al. The risk factors for residual juvenile nasopharyngeal angiofibroma and the usual residual sites. Am J Otolaryngol 2019; 40 (03) 343-346 DOI: 10.1016/j.amjoto.2018.11.010.
- 12 Lutz J, Holtmannspötter M, Flatz W. et al. Preoperative embolization to improve he surgical management and outcome of juvenile nasopharyngeal angiofibroma (JNA) in a single center: 10-year experience. Clin Neuroradiol 2016; 26 (04) 405-413
- 13 Longacre MM, Seshadri SC, Adil E, Baird LC, Goobie SM. Perioperative management of pediatric patients undergoing juvenile angiofibroma resection. A case series and educational review highlighting patient blood management. Paediatr Anaesth 2023; 33 (07) 510-519 DOI: 10.1111/pan.14655.
- 14 Bove I, Pangal DJ, Ruzevick JJ. et al. Anatomic Considerations Guiding Single Versus Multiportal Endoscopic Approaches for Resection of Juvenile Nasopharyngeal Angiofibroma: Cases Series With Graded Multicorridor Resections. Oper Neurosurg (Hagerstown) 2023; 25 (02) 150-160 DOI: 10.1227/ons.0000000000000709.
- 15 Singh RK, Lakhkar BB, Patwa PA, Mishra GV. Juvenile nasopharyngeal angiofibroma. BMJ Case Rep 2022; 15 (03) e248023 DOI: 10.1136/bcr-2021-248023.
- 16 Cohen-Cohen S, Scheitler KM, Choby G. et al. Contemporary Surgical Management of Juvenile Nasopharyngeal Angiofibroma. J Neurol Surg B Skull Base 2021; 83 (Suppl. 02) e266-e273 DOI: 10.1055/s-0041-1725031.
- 17 Song X, Wang D, Sun X. et al. Cumulative sum analysis of the learning curve for endoscopic resection of juvenile nasopharyngeal angiofibroma. Surg Endosc 2018; 32 (07) 3181-3191
- 18 Lund VJ, Stammberger H, Nicolai P. et al. European Rhinologic Society Advisory Board on Endoscopic Techniques in the Management of Nose, Paranasal Sinus and Skull Base Tumors. European position paper on endoscopic management of tumors of the nose, paranasal sinuses and skull base. Rhinol Suppl 2010; 22: 1-143
- 19 Raheja A, Sharma MS, Singh M, Agrawal D, Kale SS, Sharma SC. Adjuvant Gamma Knife Radiosurgery for Advanced Juvenile Nasopharyngeal Angiofibroma. Neurol India 2021; 69 (05) 1438-1441 DOI: 10.4103/0028-3886.329611.
- 20 Meher R, Kathuria S, Wadhwa V. et al. Preoperative emobilisation of juvenile nasopharyngeal angiofibroma. Am J Otolaryngol 2022; 43 (05) 103532 DOI: 10.1016/j.amjoto.2022.103532.
- 21 Tawfik KO, Harmon JJ, Walters Z. et al. Facial palsy following embolization of a juvenile nasopharyngeal angiofibroma. Ann Otol Rhinol Laryngol 2018; 127 (05) 344-348
- 22 Andrews JC, Fisch U, Valavanis A, Aeppli U, Makek MS. The surgical management of extensive nasopharyngeal angiofibromas with the infratemporal fossa approach. Laryngoscope 1989; 99 (04) 429-437
- 23 Felippu A. Nasal centripetal endoscopic sinus surgery. Ann Otol Rhinol Laryngol 2011; 120 (09) 581-585
- 24 Camilon PR, Rahbar R, Cunningham MJ, Adil EA. Juvenile nasopharyngeal angiofibroma in prepubertal males: A diagnostic dilemma. Laryngoscope 2019; 129 (08) 1777-1783 DOI: 10.1002/lary.27633.
- 25 Wylie JP, Slevin NJ, Johnson RJ. Intracranial juvenile nasopharyngeal angiofibroma. Clin Oncol (R Coll Radiol) 1998; 10 (05) 330-333
- 26 Overdevest JB, Amans MR, Zaki P, Pletcher SD, El-Sayed IH. Patterns of vascularization and surgical morbidity in juvenile nasopharyngeal angiofibroma: A case series, systematic review, and meta-analysis. Head Neck 2018; 40 (02) 428-443
- 27 Gargula S, Saint-Maurice JP, Labeyrie MA. et al. Embolization of Internal Carotid Artery Branches in Juvenile Nasopharyngeal Angiofibroma. Laryngoscope 2021; 131 (03) E775-E780
- 28 Liu Q, Xia Z, Hong R. et al. Preoperative Embolization of Primary Juvenile Nasopharyngeal Angiofibroma: Is Embolization of Internal Carotid Artery Branches Necessary?. Cardiovasc Intervent Radiol 2023; 46 (08) 1038-1045 DOI: 10.1007/s00270-023-03483-1.
- 29 Antonelli AR, Cappiello J, Di Lorenzo D, Donajo CA, Nicolai P, Orlandini A. Diagnosis, staging, and treatment of juvenile nasopharyngeal angiofibroma (JNA). Laryngoscope 1987; 97 (11) 1319-1325
- 30 Harrison DF. Juvenile postnasal angiofibroma–an evaluation. Clin Otolaryngol Allied Sci 1976; 1 (02) 187-197
- 31 Hackman T, Snyderman CH, Carrau R, Vescan A, Kassam A. Juvenile nasopharyngeal angiofibroma: The expanded endonasal approach. Am J Rhinol Allergy 2009; 23 (01) 95-99
- 32 Stubbs VC, Miller LE, Parasher AK, Glicksman JT, Adappa ND, Palmer J. Nasopharyngeal Angiofibroma: A Forgotten Entity in Older Patients. Clin Med Insights Case Rep 2019; 12: 1179547619841062 DOI: 10.1177/1179547619841062.
- 33 Gupta R, Agarwal SP. Juvenile Nasopharyngeal Angiofibroma: Combined Approach for Excision, Transpalatal and Endoscopic; A New Perspective. Indian J Otolaryngol Head Neck Surg 2018; 70 (01) 125-129
- 34 Boghani Z, Husain Q, Kanumuri VV. et al. Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. Laryngoscope 2013; 123 (04) 859-869
- 35 Gemmete JJ, Ansari SA, McHugh J, Gandhi D. Embolization of vascular tumors of the head and neck. Neuroimaging Clin N Am 2009; 19 (02) 181-198
- 36 Snyderman CH, Pant H, Carrau RL, Gardner P. A new endoscopic staging system for angiofibromas. Arch Otolaryngol Head Neck Surg 2010; 136 (06) 588-594
- 37 Önerci M, Oğretmenoğlu O, Yücel T. Juvenile nasopharyngeal angiofibroma: a revised staging system. Rhinology 2006; 44 (01) 39-45
- 38 Alshaikh NA, Eleftheriadou A. Juvenile nasopharyngeal angiofibroma staging: An overview. Ear Nose Throat J 2015; 94 (06) E12-E22
- 39 Radkowski D, McGill T, Healy GB, Ohlms L, Jones DT. Angiofibroma. Changes in staging and treatment. Arch Otolaryngol Head Neck Surg 1996; 122 (02) 122-129
- 40 Chandler JR, Goulding R, Moskowitz L, Quencer RM. Nasopharyngeal angiofibromas: staging and management. Ann Otol Rhinol Laryngol 1984; 93 (4 Pt 1): 322-329
- 41 Fisch U. The infratemporal fossa approach for nasopharyngeal tumors. Laryngoscope 1983; 93 (01) 36-44
- 42 Sessions RB, Bryan RN, Naclerio RM, Alford BR. Radiographic staging of juvenile angiofibroma. Head Neck Surg 1981; 3 (04) 279-283
- 43 Blount A, Riley KO, Woodworth BA. Juvenile nasopharyngeal angiofibroma. Otolaryngol Clin North Am 2011; 44 (04) 989-1004 , ix
- 44 Khoueir N, Nicolas N, Rohayem Z, Haddad A, Abou Hamad W. Exclusive endoscopic resection of juvenile nasopharyngeal angiofibroma: a systematic review of the literature. Otolaryngol Head Neck Surg 2014; 150 (03) 350-358
- 45 Petruson K, Rodriguez-Catarino M, Petruson B, Finizia C. Juvenile nasopharyngeal angiofibroma: long-term results in preoperative embolized and non-embolized patients. Acta Otolaryngol 2002; 122 (01) 96-100
- 46 Tseng EY, Narducci CA, Willing SJ, Sillers MJ. Angiographic embolization for epistaxis: a review of 114 cases. Laryngoscope 1998; 108 (4 Pt 1): 615-619
- 47 Siniluoto TM, Leinonen AS, Karttunen AI, Karjalainen HK, Jokinen KE. Embolization for the treatment of posterior epistaxis. An analysis of 31 cases. Arch Otolaryngol Head Neck Surg 1993; 119 (08) 837-841
- 48 Andrade NA, Pinto JA, Nóbrega MdeO, Aguiar JE, Aguiar TF, Vinhaes ES. Exclusively endoscopic surgery for juvenile nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg 2007; 137 (03) 492-496
- 49 Bhardwaj A, Priya M, Malhotra M, Varshney S, Tyagi AK, Singh A. Novel Modifications to Total Maxillary Swing Approach in Extensive Nasopharyngeal Angiofibroma to Minimize Complications. Indian J Otolaryngol Head Neck Surg 2022; 74 (Suppl. 02) 1120-1127
- 50 Gupta DP, Gupta S, Shreevidya SR. Endoscopic Modified Denker's Approach for the Treatment of Juvenile Nasopharyngeal Angiofibroma. Indian J Otolaryngol Head Neck Surg 2022; 74 (Suppl. 02) 921-928