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Semin Reprod Med 2023; 41(05): 190-199
DOI: 10.1055/s-0043-1778056
DOI: 10.1055/s-0043-1778056
Review Article
The Upper Reproductive System Microbiome: Evidence beyond the Uterus
Funding This study was funded by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and the European Regional Development Fund (FEDER) through MCIN/AEI/10.13039/501100011033 and ERFD's “A way of making Europe projects”, specifically Endo-Map PID2021-12728OB-100 and ROSY CNS2022-135999. A.C.G.'s funding was provided by the “Plan de Recuperación, Transformación y Resiliencia”, specifically under the “Ayudas para la recualificación del sistema universitario español” and “Ayudas Margarita Salas para la formación de jóvenes doctores” at Universidad de Murcia. A.S.L. received funding from the Becas Fundación Ramón Areces para Estudios Postdoctorales, within the XXXV Convocatoria para Ampliación de Estudios en el Extranjero en Ciencias de la Vida y de la Materia. Additionally, this work was supported by the European Union's Horizon 2020 research and innovation program “ERIN” (grant ID EU952516).
Abstract
The microbiome of the female upper reproductive system has garnered increasing recognition and has become an area of interest in the study of women's health. This intricate ecosystem encompasses a diverse consortium of microorganisms (i.e., microbiota) and their genomes (i.e., microbiome) residing in the female upper reproductive system, including the uterus, the fallopian tubes, and ovaries. In recent years, remarkable advancements have been witnessed in sequencing technologies and microbiome research, indicating the potential importance of the microbial composition within these anatomical sites and its impact in women's reproductive health and overall well-being. Understanding the composition, dynamics, and functions of the microbiome of the female upper reproductive system opens up exciting avenues for improving fertility, treating gynecological conditions, and advancing our comprehension of the intricate interplay between the microbiome and the female reproductive system. The aim of this study is to compile currently available information on the microbial composition of the female upper reproductive system in humans, with a focus beyond the uterus, which has received more attention in recent microbiome studies compared with the fallopian tubes and ovaries. In conclusion, this review underscores the potential role of this microbiome in women's physiology, both in health and disease.
* These authors contributed equally.
Publikationsverlauf
Artikel online veröffentlicht:
06. Februar 2024
© 2024. Thieme. All rights reserved.
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