Endoscopy 2025; 57(S 02): S81
DOI: 10.1055/s-0045-1805253
Abstracts | ESGE Days 2025
Oral presentation
Stomach Pot Pourri 04/04/2025, 08:30 – 09:30 Room 124+125

Gastric electrical stimulation combined with pyloromyotomy or pyloroplasty in gastroparesis patients: a systematic review and meta-analysis

A A Awad
1   Faculty of Medicine Al-Azhar University Boy's Branch in Cairo, Cairo, Egypt
2   Medical Research Group of Egypt (MRGE), Cairo, Egypt, Cairo, Egypt
,
MA Aldemerdash
3   Faculty Of Medicine Sohag university, Sohag, Egypt
,
A Y Shaban
4   Faculty of Medicine, Kafr El-Shaikh, Egypt
,
A Aldemerdash
3   Faculty Of Medicine Sohag university, Sohag, Egypt
,
A Omar Abd El Hafez
5   Faculty of medicine Sohag University, Sohag, Egypt, Sohag, Egypt
,
A Mostafa Amin
6   Faculty of Medicine, Al-Azhar University, Girls Branch, Cairo, Cairo, Egypt
,
M Nabil
7   Faculty of Medicine, Menoufia University, Egypt, Minuf, Egypt
,
M Mahmoud Elgamal
8   Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt, Kafr El-Shaikh, Egypt
,
A Abdallah
9   School of Medicine, The University of Jordan, Amman, 11942, Jordan., Amman, Jordan
,
M Mahmoud Marey
10   Alexandria Faculty of Medicine, Alexandria, Egypt
,
A Saeed
11   Faculty of Medicine,Al-Azhar University, Damietta,Egypt, damietta, Egypt
,
O Saeed
11   Faculty of Medicine,Al-Azhar University, Damietta,Egypt, damietta, Egypt
,
M Mohamed Abdelkareem
3   Faculty Of Medicine Sohag university, Sohag, Egypt
,
A M Othman
4   Faculty of Medicine, Kafr El-Shaikh, Egypt
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Aims Gastroparesis (GP) is a chronic disorder characterized by delayed gastric emptying without mechanical obstruction. It significantly impacts the quality of life. Gastric electrical stimulation (GES) has been used as an important treatment option to improve symptoms in patients with GP who are refractory to medical therapy. According to recent research, the pyloroplasty procedure could improve the therapeutic benefits of GES. In patients with refractory GP, the combined use of GES with adjunct pyloroplasty (PS) or pyloromyotomy (PM) is the focus of this systematic review and meta-analysis.

Methods We identified studies involving GP patients who underwent GES with adjunct pyloroplasty or pyloromyotomy. A literature search was done through PubMed, Web of Science, Scopus, Embase, and Cochrane databases from inception until September 2024. The primary outcomes included Gastroparesis Cardinal Symptom Index (GCSI), along with secondary outcomes, bloating, postprandial fullness, early satiety, and gastric retention at 4 hours. The data were analyzed using R version 4.4.1.

Results Eleven observational studies were identified with a total of 687 patients enrolled. GES with adjunct pyloroplasty PS or PM at the GCSI score, bloating, postprandial fullness, early satiety, and gastric retention at 4 hours compared with PS or PM alone (MD=-0.84, 95% CI (-2 to 0.31) p=0.07, I2=0), (MD=0.23, 95% CI (-1.16 to 0.7), p=0.31, I2=0), (MD=0.09, 95% CI (-0.08 to 0.26), I2=0),(MD=-0.23, 95% CI (-0.42 to -0.04), I2=0) and (MD=-3.99, 95% CI (-10.53 to 2.55), I2=0) respectively.

Conclusions : This systematic review and meta-analysis conclude that GES in combination with an adjunct has a potentially promising role in improving gastroparesis-related symptoms, particularly early satiety when compared to PS or PM alone. Further research, particularly randomized controlled trials, is required to confirm these preliminary results and assess the long-term benefits and safety of treating GES with PS or PM in patients with refractory gastroparesis.



Publikationsverlauf

Artikel online veröffentlicht:
27. März 2025

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