Endoscopy 2025; 57(S 02): S242
DOI: 10.1055/s-0045-1805592
Abstracts | ESGE Days 2025
Moderated poster
Endoscopic management of pancreatic diseases 04/04/2025, 14:00 – 15:00 Poster Dome 2 (P0)

Early Chronic Pancreatitis (CP) and Factors Associated with the Long-Term Progression of the Disease

Y Dominguez-Novoa
1   University Hospital of Santiago. Foundation Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain
,
J Iglesias-Garcia
2   Santiago Clinic Hospital CHUS, Santiago de Compostela, Spain
,
J Lariño Noia
3   University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
,
X F Martinez-Seara
3   University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
,
P Miguez-Sanchez
4   Foundation Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain
,
L Nieto-Garcia
3   University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
,
MD S Porto-Silva
3   University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
,
J E Dominguez-Munoz
1   University Hospital of Santiago. Foundation Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain
› Author Affiliations
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Aims to evaluate the long-term morphological behavior of mild EUS changes of CP and the factors associated with progression to suggestive or consistent CP.

Methods A prospective, longitudinal cohort study was designed. Patients with epigastric pain, toxic habits (alcohol and/or smoking), mild changes of CP at initial EUS (3 or 4 minor criteria, indeterminate for CP), and with a minimum clinical and EUS follow-up of 5 years were included. Morphological progression was defined as developing suggestive or definite EUS criteria of CP (≥ 5 criteria) during follow-up. Multivariate logistic regression analysis was performed (results presented as OR, 95%CI).

Results 136 patients were included (mean age 56.5±13.3 years, 64.7% male). EUS changes progressed in 84 patients (61.8%) over a median follow-up of 8.7 years (range 5.1-14.8 years), whereas the remaining 52 patients (38.2%) did not progress. Age and gender were similar in the two groups (p=0.716). The risk of progression of morphological findings of CP was associated with smoking (OR 86.36 (16.74-445-50; p<0.001), alcohol intake (OR 10.59 (3.49-32.14); p<0.001) and smoking and alcohol intake together (OR 150.43 (17.49-1293.97); p<0.001). Smoking cessation (OR 0.24, 0.07-0.86, p=0.028) and alcohol cessation (OR 0.21, 0.06-0.82, p=0.024) were associated with lack of morphological progression of mild EUS changes of CP. Smoking, but not alcohol consumption during follow-up was associated with persistent abdominal pain (OR 5.30, 2.02-13.9, p=0.001).

Conclusions In patients with epigastric pain and toxic habits, the presence of mild indeterminate EUS changes of CP is suggestive of early CP. Maintaining smoking and alcohol consumption in these patients is associated with morphological progression for CP, whereas quitting toxic habits is protective against progression. Smoking during follow-up is associated with persistent epigastric pain.



Publication History

Article published online:
27 March 2025

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