Menetrier's Disease: A Case Report with partial endoscopic regression after one year follow up in a 32-year old man

Ménétrier's disease is a rare gastric disorder characterized by the hypertrophy of the gastric mucosa, predominantly affecting the gastric body and fundus. Condition is often associated with significant gastrointestinal symptoms. We present a 32-year-old male who presented with nausea and vomiting, leading to dehydration and acute kidney injury. Initial gastroscopy revealed edematous and hyperemic gastric folds, and biopsy findings were suggestive of Ménétrier's disease. Among the extensive diagnostic evaluations performed, cytomegalovirus (CMV) serology returned positive, prompting the initiation of antiviral therapy with valganciclovir. The patient was subsequently referred to our clinic, where a repeat gastroscopy with endoscopic mucosal resection of two gastric folds confirmed the diagnosis of Ménétrier's disease. Proton pump inhibitors and metoclopramide were administered, resulting in symptom improvement. Due to the presence of proteinuria, a kidney biopsy was performed, revealing mild changes consistent with post-infectious glomerulonephritis, although a direct correlation with Ménétrier's disease could not be established. Treatment with an ACE inhibitor was initiated. A clinical follow-up conducted four months after the initial diagnosis revealed sufficient symptom improvement to warrant the discontinuation of metoclopramide. Nine months after the diagnostic procedure, a second gastroscopy demonstrated significant regression of the gastric mucosal hypertrophy, though some localized changes persisted. The patient’s gastrointestinal symptoms largely resolved, and renal function stabilized with continued ACE inhibitor therapy. Surveillance endoscopy is planned for one year following the second procedure [1].

Publication History

Article published online:
27 March 2025

• References

• 1 Kiwan W, Gong Y, Buxbaum J.. Ménétrier Disease: A Rare Cause of Iron Deficiency Anemia. Clin Gastroenterol Hepatol 2023; 21 (5): A18 Epub 2022 Oct 2936441094