Connecting Clots and Crisis: Exploring the Role of D-Dimer in Diagnosing Mesenteric Ischemia

Aims This study explores the link between elevated D-dimer levels and mesenteric ischemia, a critical vascular condition. D-dimer, a byproduct of clot breakdown, is often raised when clots form and dissolve. Mesenteric ischemia, which arises from decreased intestinal blood flow, poses severe risks. We examine if high D-dimer levels can signal this disease, potentially aiding in its diagnosis. By analyzing clinical data, we aim to clarify this relationship, focusing on its potential for early detection and enhancing outcomes for patients with mesenteric ischemia

Methods Our retrospective study, from 2009-2023, analyzed Mesenteric ischemia patients in the Nationwide Inpatient Sample. We collected data on comorbidities, D-dimer levels, gender, race, insurance, and socioeconomic factors using CPT and ICD codes. Initial analysis focused on the distribution of D-dimer levels and mesenteric ischemia prevalence. We employed the Mann-Whitney U test to compare medians between groups and Spearman's rank correlation coefficient to measure the association strength between D-dimer levels and mesenteric ischemia, finding a moderate, significant correlation.

Results A total of 7854 patients diagnosed with Mesenteric ischemia were included in the study. 4398 (54%) were female. The average age in the study is 58±7 years. The average BMI in the study group was 31±10. Among the races, The Mann-Whitney U test (10.5 p<0.01) showed a higher D dimer level was associated with Mesenteric ischemia Similarly, the Spearman correlation coefficient of approximately 0.260 (p<0.05) demonstrates a moderate positive correlation between D-dimer levels and mesenteric ischemia, further supporting this association.

Conclusions The results of our study reveal a noteworthy association between elevated D-dimer levels and mesenteric ischemia. The Mann-Whitney U test indicated significantly higher D-dimer levels in patients with mesenteric ischemia, reinforcing the potential of D-dimer as a marker for this condition. Furthermore, the Spearman correlation's moderate positive coefficient strengthens the evidence for this link. These findings suggest that monitoring D-dimer levels could aid in the early identification of mesenteric ischemia, potentially improving patient outcomes through timely intervention. However, the study highlights the need for cautious interpretation and consideration of other influencing factors in clinical settings.

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Artikel online veröffentlicht:
27. März 2025