Endoscopy 2025; 57(S 02): S346-S347
DOI: 10.1055/s-0045-1805861
Abstracts | ESGE Days 2025
ePosters

Successful Management of Recurrent Gastrointestinal Bleeding in Metastatic Cholangiocarcinoma Using Calcium Electroporation

Authors

  • A Gómez Gómez

    1   Virgen of Arrixaca University Clinical Hospital, El Palmar, Spain

  • M Romero Martínez

    1   Virgen of Arrixaca University Clinical Hospital, El Palmar, Spain

  • R Fernández Nievas

    1   Virgen of Arrixaca University Clinical Hospital, El Palmar, Spain

  • F J Sánchez Roncero

    2   Rafael Méndez University General Hospital, Lorca, Spain

  • C Bógalo Romero

    1   Virgen of Arrixaca University Clinical Hospital, El Palmar, Spain

  • L Madrigal Bayonas

    2   Rafael Méndez University General Hospital, Lorca, Spain

  • G Calatayud Vidal

    2   Rafael Méndez University General Hospital, Lorca, Spain

  • J Egea Valenzuela

    1   Virgen of Arrixaca University Clinical Hospital, El Palmar, Spain
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We report the case of a 36-year-old woman with recurrent gastrointestinal bleeding due to cholangiocarcinoma with duodenal metastasis, necessitating multiple blood transfusions. The patient initially received haemostatic radiotherapy and several lines of chemotherapy, but the bleeding persisted. Consequently, endoscopic electroporation with intratumoral calcium injection in the duodenal lesion, combined with systemic chemotherapy, was initiated. Following the first session [Figure 1], bleeding ceased within a few days. During the second session, one month later, the tumor tissue appeared pale, with no visible vessels or spontaneous bleeding [Figure 2]. The patient has now been free of transfusion requirements for eight months and remains asymptomatic.

Calcium electroporation is an anti-cancer treatment in which high calcium concentrations are introduced into cells through electroporation, a technique using brief, high-voltage pulses to induce temporary permeabilization of the plasma membrane, allowing calcium to enter the cytosol. Electroporation can also be performed with agents like bleomycin or cisplatin. Currently, no clinical practice guidelines exist for endoscopic electroporation, though small studies show promising results for palliative management of obstructive symptoms and bleeding in various digestive tumors, including esophageal and colorectal cancer [1] [2] [3].



Publikationsverlauf

Artikel online veröffentlicht:
27. März 2025

© 2025. European Society of Gastrointestinal Endoscopy. All rights reserved.

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