Examining Demographic Variations in Eosinophilic Esophagitis: A Nationwide Study of Hospital Admissions (2019-2023)

Aims Eosinophilic esophagitis (EoE) is an inflammatory condition that varies widely in incidence across different racial and gender groups. This study examines how race and gender influence the prevalence of EoE, exploring patterns and disparities. The research aims to identify which groups are most at risk through detailed statistical analysis, thereby informing targeted medical interventions and increasing awareness of the demographic variations in this chronic disease.

Methods Data from the Nationwide Admission Database (HCUP) for 2019-2023 on 1,748,576 adult hospital admissions with a primary diagnosis of Eosinophilic esophagitis was analyzed. The study began with an inspection of the dataset's structure, emphasizing race, gender, and eosinophilic esophagitis indicators. Incidence rates were summarized by demographics, followed by chi-square tests to identify significant incidence variations among different racial and gender groups, using contingency tables for statistics and p-values. Logistic regression was then applied to further explore these associations, with race and gender as predictors, and eosinophilic esophagitis as the dependent outcome

Results Between 2019 and 2023, 1,748,576 patients were admitted; 11051 Eosinophilic esophagitis patients were studied after propensity score matching. Logistic regression analysis highlights significant racial and gender disparities in eosinophilic esophagitis incidence. White individuals have the highest likelihood (coefficient: 2.2411, p<0.0001), with Blacks also at increased risk (coefficient: 1.0911, p<0.0001). Conversely, Other Races have a reduced likelihood (coefficient: –1.0702, p<0.0001). No significant odds difference is seen in Hispanics (coefficient: –0.0102, p=0.9742). Males are less likely to develop the condition than females (coefficient: –0.1760, p<0.0001), emphasizing race and gender's role in the disease's prevalence

Conclusions The study highlights significant racial and gender disparities in eosinophilic esophagitis (EoE) incidence, emphasizing the need for tailored healthcare strategies. Increased prevalence among White and Black populations suggests potential genetic or environmental influences, while the higher incidence in females may indicate hormonal or immune variations. These findings support the development of customized medical approaches that consider these demographic factors to improve treatment outcomes and efficacy in EoE management

Publikationsverlauf

Artikel online veröffentlicht:
27. März 2025