Endoscopy 2025; 57(S 02): S377
DOI: 10.1055/s-0045-1805950
Abstracts | ESGE Days 2025
ePosters

Anthropometric measurements, body composition and predictive role of phase angle in weight loss after bariatric endoscopy: results from two single-center, randomized trials

S F Vadalà Di Prampero
1   Digestive Endoscopy Unit, Ospedale Fatebenefratelli Gemelli Isola Tiberina, Rome, Italy
,
V Cosseddu
2   Mater Olbia Hospital, Olbia, Italy
,
J Formichetti
2   Mater Olbia Hospital, Olbia, Italy
,
S Masia
2   Mater Olbia Hospital, Olbia, Italy
,
C Rocchi
2   Mater Olbia Hospital, Olbia, Italy
,
M Massidda
2   Mater Olbia Hospital, Olbia, Italy
,
P Bazzu
2   Mater Olbia Hospital, Olbia, Italy
,
P Giustacchini
3   Agostino Gemelli University Policlinic, Rome, Italy
,
G Costamagna
1   Digestive Endoscopy Unit, Ospedale Fatebenefratelli Gemelli Isola Tiberina, Rome, Italy
,
M Bulajic
1   Digestive Endoscopy Unit, Ospedale Fatebenefratelli Gemelli Isola Tiberina, Rome, Italy
› Institutsangaben
 

Aims In the era of pandemic obesity endoscopic bariatric therapy (EBT) is becoming even more common to treat obese patients less invasively than surgery. Nowadays two procedures are mainly widespread: space-occupying procedures through intragastric balloons (IGB) and restrictive procedures through endoscopic gastroplasty (EG). Our study aims to assess changes in anthropometric measurements and body composition after EBT looking for any predictive factors of weight loss related to the procedures in the short-term.

Methods Two single-center, randomized trials of patients who underwent EBT through IGB (ClinicalTrials.gov NCT06673550) or EG (ClinicalTrials.gov NCT04854317) were considered. Primary outcome concerned the efficacy of the EBT procedures at improving the body circumferences (arm, waist, hip and calf) and the body composition (fat mass (FM), free fat mass (FFM), body cell mass (BCM)). Secondary outcome was to detect any predictive factors of weight loss related to the procedures analyzed. As time frame for analysis, we considered the 6-month follow-up, when we used to remove the IGB.

Results Between July 2020 and January 2024, 318 obese patients were analyzed: 156 underwent IGB (mean age 46±14 years; females 69.2%; body mass index 41.9±9.1 kg/m2; obesity class III as the main obesity class in 53.0% of cases) and 162 underwent EG (mean age 46±10 years; females 87.5%; body mass index 36.6±3.1 kg/m2; obesity class II as the main obesity class in 58.3%). The follow-up visit at 6 months was attended by 146/156 (93.5%) patients in IGB group and by 114/162 (70.4%) patients in the EG group. They experienced respectively 14.2±7.1% and 16±6% total body weight loss (TBWL), and 30.8±23.3% and 39.7±14.9% excess weight loss (EWL). In both groups all the body circumferences homogeneously decreased (p<0.001). Concerning the body composition, the FM and FM% significantly decreased (p<0.001), while the FFM% (p<0.001) and BCM% (p<0.05) increased. By a linear regression analysis, at 6 months follow-up a significant correlation between the Phase Angle and the percentage of TBWL (r=0.327, p<0.05) and EWL (r=0.274, p<0.05) was detected in EG group, while in the IGB group this correlation wasn’t found, probably because the baseline features of the two groups were different (mainly regarding BMI) and the mechanisms of weight loss are different in the two groups and the EBTs are different themself.

Conclusions EBTs through IGB and EG seem to be effective for the treatment of obese patients inducing weight loss, improving the anthropometric measurements and the body composition. The Phase Angle could be considered a predictor of weight loss in some EBTs, getting a role in the personalized therapy for obesity.



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Artikel online veröffentlicht:
27. März 2025

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